Influence of epstein-barr virus infection on immunologic function and myocardial fibrosis in patients with coronary heart disease complicated by heart failure
Jia Zhengpei
Sun Jing
Ren Hongkun
Wu Yuntao
Abstract：Objective To discuss the influence of epstein-barr virus (EBV) infection on immunologic function and myocardial fibrosis in patients with coronary heart disease complicated by heart failure (CHD+HF).Methods CHD+HF patients were chosen from Department of Cardiology in People's Hospital of Inner Mongolia Autonomous Region from Jan.2019 to Dec.2022.The load of serum EBV DNA was detected by using reverse transcription polymerase chain reaction (RT-PCR).All patients were divided,according to EBV DNA detection results,into infection group (n=29) and non-infection group (n=91).The relationship among different grades of heart function classification and EBV infection was analyzed.The indexes of myocardial fibrosis[type Ⅰ procollagen carboxy-terminal peptide (PICP),type Ⅲ procollagen N-terminal peptide (PIIINP),matrix metalloproteinase-2 (MMP-2),matrix metalloproteinase-9 (MMP-9)]and cellular immunology function indexes (CD3+,CD4+,CD8+,CD4+/CD8+T cells) were detected in 2 groups.The relationship among EBV DNA load,indexes of myocardial fibrosis and indexes of cellular immunological function were analyzed by using Pearson correlation analysis.Results The grades of heart function classification were positively correlated to EBV DNA load (r=0.564,P=0.002) in infection group.The levels of PⅠCP,PⅢNP,MMP-9,MMP-2 and CD8+were significantly higher,and levels of CD3+,CD4+and CD4+/CD8+were significantly lower in infection group than those in non-infection group (P＜0.05).EBV DNA load was positively correlated to levels of PⅠCP,PⅢNP,MMP-9,MMP-2 and CD8+(r=0.439,r=0.544,r=0.435,r=0.422,r=0.489,P＜0.05),and negatively correlated to levels of CD3+,CD4+and CD4+/CD8+(r=-0.699,r=-0.757,r=-0.642,P＜0.001).Conclusion EBV infection can possibly inhibit cellular immunological function,improve myocardial fibrosis progression,and further damage heart function in CHD+HF patients.
Keywords：Coronary heart diseaseHeart failureEpstein-barr virusMyocardial fibrosisCellular immunological function
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1516-1519 )