Relationship between expression of serum microRNA-451a and heart failure after intervention for acute myocardial infarction
Luo Zhengyi
Zhou Wenjie
Abstract：Objective To investigate the relationship between expression of serum microRNA-451a (miR-451a) and heart failure (HF) after intervention for acute myocardial infarction (AMI).Methods The patients with ST-segment elevation myocardial infarction (STEMI,n=140) undergone PCI were chosen from Rugao Hospital affiliated to Nantong University from Nov.2019 to Deb.2021.The patients were divided,according to HF occurrence after PCI,into non-HF group (n=106) and HF group (n=34).The clinical data and levels of serum miR-451a and macrophage migration inhibitory factor (MIF) were compared between 2 groups.The correlation between serum miR-451a and MIF was analyzed in patients with STEMI complicated by HF after PCI.The influence factors for HF occurrence after PCI were analyzed.The predictive value of miR-451a and MIF to complicated HF was analyzed in STEMI patients after PCI.Results The percentages of patients aged≥60,with diseased vessels≥2,diabetes,time from onset to PCI≥12 h,hypertension and hyperlipidemia,and MIF level were higher (P＜0.05),and percentages of patients with left ventricular ejection fraction (LVEF) ≥50％ and miR-451a expression were lower (P＜0.05) in HF group than those in non-HF group.The level of serum miR-451a was negatively correlated to MIF (r=-0.484,P＜0.05),and MiR-451a and LVEF were protective factors for HF in HF group after PCI (OR=0.553,0.679,P＜0.05).Age,time from onset to PCI,diabetes,number of diseased vessels,hyperlipidemia,hypertension and MIF were risk factors for HF after PCI (OR=2.208,2.187,2.572,2.394,2.456,2.630,2.781,P＜0.05).In prediction of HF by miR-451a and MIF,AUC was,respectively,0.878 and 0.862,cutoff value was,respectively,0.74 ng/ml and 79.32 ng/ml,sensitivity was,respectively,79.4％ and 76.5％,and both specificities were 87.7％.In prediction of HF by miR-451a combined with MIF,AUC was 0.938,sensitivity was 91.2％ and specificity was 86.8％.Conclusion The expression of serum miR-451a is lower in STEMI patients complicated by HF,which is negatively correlated to MIF significantly,and detection of MIF combined with miR-451a can predict HF better in STEMI after PCI.
Keywords：ST-segment elevation myocardial infarctionHeart failurePercutaneous coronary interventionMicroRNA-451a
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1471-1474 )