Correlation among ambulatory pulse pressure,trace element changes and carotid artery intima-media thickness in patients with primary hypertension
Zhang Yuxin
Zhang Zhiliang
Li Jingchang
Feng Wenhua
Abstract：Objective To discuss the correlation among ambulatory pulse pressure (APP),trace element changesandcarotid artery intima-media thickness (CIMT) in patients with primary hypertension (PH).Methods PH patients were chosen into study group (n=187),and healthy controls were chosen in healthy group (n=150) in Department of Cardiovascular Medicine in Central Hospital of Nanyang City.The general clinical materials were collected after patient hospitalized.The levels of APP and serum trace elements (iron,zinc,calcium) and CIMT value were detected.The general data,levels ofAPP and trace elements and CIMT value were compared between 2 groups.The patients were divided,according CIMT value,into normal CIMT subgroup and thickened CIMT subgroup,and levels of APP and trace elements and CIMT value were compared between 2subgroups.The correlation among APP,trace elements and CIMT was analyzed by using Pearson correlation coefficient analysis.The relative factors affecting CIMT value were analyzed by using multi-factor Logistic regression analysis in PH patients.Results Age,body mass index (BMI),24 h systolic blood pressure (24h SBP),24 h diastolic blood pressure (24h DBP),triglyceride (TG),low-density lipoprotein-cholesterol (LDL-C),levels of APP,iron and calcium and CIMT value all were significantly higher (P＜0.05),and zinc level was significantly lower (P＜0.05) in study group than those in healthy group.The differences in gender,smoking and drinking history,heart rate,fasting plasma glucose (FPG),total cholesterol (TC) and high-density lipoprotein-cholesterol (HDL-C) had no statistical significance between 2 groups (P＞0.05).The levels of APP andiron and calcium were significantly higher (P＜0.05),and zinc level was significantly lower (P＜0.05) in thickened CIMT subgroup than those in normal CIMT subgroup.The result of Pearson correlation coefficient analysis showed that CIMT was positively correlated to levels of APP,iron and calcium (P＜0.05),and negatively correlated to zinc level (P＜0.05).The results of multi-factor Logistic regression analysis showed that BMI,24h SBP,24h DBP,and levels of APP,iron and calcium were risk factors for CIMT thickening (P＜0.05),and zinc level was a protective factor (P＜0.05) in PH patients.Conclusion Increased levelsof APP and abnormal trace elements can be observed in PHpatients,and both of them are significantly correlated to CIMT thickening.
Keywords：Primary hypertensionAmbulatory pulse pressureCarotid artery intima-media thickness
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1445-1448 )