Risk factors related to cardiovascular diseases in patients with hypertension:a Meta-analysis
Qian Xiyan
Tang Yifan
Li Tingru
Gao Chunhong
Fan Yunxia
Mei Kewen
Abstract：Objective To analyze and summarize risk factors related to cardiovascular diseases (CVD) in patients with hypertension through a Meta-analysis,and provide evidence-based medical grounds for advancing prevention and treatment of CVD.Methods The databases of Cochrane Library,PubMed,EMbase,Web of Science and CINAHL were retrieved for searching published English literature on risk factors related to CVD occurred in hypertensive patients up to Dec.2022.The relevant data in included literature was extracted by 2 researchers independently,and given a Meta-analysis by using Revman 5.3 software.Results A total of 60 articles and 19 risk factors involving 2659691 patients were included.The results of Meta-analysis showed that being male (OR=1.46,95％CI:1.23～1.74),aging (OR=0.36,95％CI:0.26～0.50),diabetes (OR=2.06,95％CI:1.53～2.78),higher cholesterol level (OR=0.59,95％CI:0.40～0.88),reduced glomerular filtration rate (GFR,OR=2.61,95％CI:2.05～3.32),anemia (OR=2.5,95％CI:1.80～3.42),obstructive sleep apnea syndrome (OSAS,OR=2.2,95％CI:1.62～2.99),low physical condition (OR=1.52,95％CI:1.00～2.31),poor blood pressure control (OR=0.55,95％CI:0.40～0.76),history of hypertension treatment (OR=1.4,95％CI:1.15～1.70),and depression (OR=1.81,95％CI:1.44～2.29) all were significant risk factors for CVD occurrence in hypertensive patients (P＜0.05).The results of subgroup analysis showed that male hypertensive patients had a higher risk of coronary heart disease (CHD) than female patients,patients with higher age and elevated urine protein (UP) had a higher risk of CVD death (P＜0.05).Conclusion Being male,aging,diabetes,higher cholesterol level,reduced GFR,anemia,OSAS,low physical condition,poor blood pressure control,history of hypertension treatment and depression all are risk factors for CVD occurrence in hypertensive patients.The conclusion suggests that the focus of primary prevention of CVD in the patients should be on optimizing the management of comorbidities,controlling primary disease and enhancing physical fitness.
Keywords：HypertensionCardiovascular diseasesRisk factorsMeta-analysis
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 1416-1423 )