Predictive value of result parameters of cardiopulmonary exercise testing to outcomes in anxiety patients with coronary heart disease after PCI
Li Peng
Li Juan
Jia Runan
Wang Dongling
Abstract：Objective To discuss the predictive value of result parameters of cardiopulmonary exercise testing(CPET)to outcomes in anxiety patients with coronary heart disease(CHD)after PCI.Methods The clinical data of CHD patients received PCI(n=847)were retrospectively analyzed in Huaihe Hospital of Henan University from Jan.2016 to Dec.2018.The information of follow-up and death were described in all patients within 5 y after PCI.The death information was given single-factor and multi-factor analyses in CHD patients with anxiety within 5 y after PCI.A predictive model was established and its predictive effectiveness on death was analyzed in CHD patients with anxiety after PCI.Results All patients were followed up for 1427 d after PCI.Among all patients included the study,there were 68 died patients and 779 survival ones after PCI for 5 y.The results of single-factor analysis showed that differences in predicted percentage of forced vital capacity(FVC％),minimum carbon dioxide ventilation equivalent(VE/VCO2)and 3 min post-exercise heart rate recovery(HRR)had statistical significance between died patients and survival ones within 5 y after PCI.The results of multi-factor analysis showed that FVC％,VE/VCO2 and HRR were independent influence factors for death in CHD patients with anxiety after PCI for 5 y(P＜0.05).A nomogram risk model was established based on the variables screened by multi-factor analysis,and C-index was 0.723.Bootstrap self-sampling method was used for internal verification,and self-sampling was repeated for 1000 times to obtained a calibration curve with an average absolute error of 0.008.The results of decision analysis curve showed that the probability of comprehensive risk threshold was 11％-51％,and net benefit rate was＞0.The independent influence factors in regression model and P-value prediction probability were used to predict the death in ROC curve in CHD patients with anxiety after PCI for 5 y,and Youden index was,respectively,33.14％,34.82％,39.61％and 53.06％.Conclusion The outcomes of CHD patients with postoperative anxiety are correlated to CPET parameters of FVC％,VE/VCO2 and HRR,and the predictive model based on various influence factors can predict well patients'outcomes.
Keywords：Coronary heart diseaseCardiopulmonary exercise testingAnxietyOutcomesVital capacity
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1345-1349 )