Predictive value of levels of preoperative cardiac troponin Ⅰ,N-terminal pro-brain natriuretic peptide and D-dimer to no-reflow in patients with acute coronary syndrome during PCI
Li Shiliang
Zhang Jinrui
Zhao Yingxuan
Liu Caixia
Abstract：Objective To discuss the predictive value of levels of preoperative cardiac troponin Ⅰ(cTnⅠ),N-terminal pro-brain natriuretic peptide(NT-proBNP)and D-dimer(D-D)to no-reflow in patients with acute coronary syndrome(ACS)during percutaneous coronary intervention(PCI).Methods ACS patients(n=120)were chosen from Zhengzhou Yihe Hospital from Jan.2021 to Jan.2023,and all of them were given PCI within 12 h after ACS onset.The patients were divided into normal flow group(n=98)and no reflow group(n=22)according to blood flow after thrombolysis in myocardial infarction during PCI.The levels of preoperative serum cTnⅠ,NT-proBNP and D-D and clinical materials were compared between 2 groups.The influence factors for no-reflow were analyzed by using multi-factor regression analysis,and predictive value of levels of preoperative serum cTnⅠ,NT-proBNP and D-D to no-reflow was analyzed by using ROC curve.Results The levels of preoperative serum cTnⅠ,NT-proBNP and D-D were higher(P＜0.05),age was older(P＜0.05),and hypertensive patients were more(P＜0.05)in no reflow group than those in normal flow group.The results of regression analysis showed that higher levels of preoperative cTnⅠ,NT-proBNP and D-D were risk factors for no-reflow in ACS patients during PCI.The results of ROC curve analysis showed that cTnⅠ(AUC=0.873,95％CI:0.791-0.956,P＜0.001),NT-proBNP(AUC=0.921,95％CI:0.864-0.978,P＜0.001)and(AUC=0.827,95％CI:0.727-0.927,P＜0.001)had higher diagnostic value to no-reflow in ACS patients during PCI.Conclusion The high levels of preoperative cTnⅠ,NT-proBNP and D-D are risk factors for no-reflow in ACS patients during PCI,and they have some predictive value to no-reflow occurrence,and predictive value of NT-proBNP is higher.
Keywords：Acute coronary syndromePercutaneous coronary interventionNo-reflowCardiac troponin ⅠN-terminal pro-brain natriuretic peptideD-dimer
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1323-1326 )