Clinical summary of endomyocardial biopsy in patients with cardiac amyloidosis
Wu Lina
Zhu Hong
Pan Xiaohong
Abstract：Objective To investigate the clinical application and experience of endomyocardial biopsy in patients with cardiac amyloidosis in a third class hospital.Methods The clinical manifestations and pathological findings of 42 patients with cardiac amyloidosis confirmed by endomyocardial biopsy were retrospectively analyzed.Results The pathological results of endomyocardial biopsy were mainly positive for Congo red staining under light microscope,apple green birefringence under polarized light,and amyloid fiber deposition in the stroma under electron microscopy.By immunohistochemistry,immunoelectron microscopy,mass spectrometry and gene detection were performed in some patients,40 cases of immunoglobulin light chain type were identified,including 34 cases of λtype,6 cases of K type,and 2 cases of transthyretin type.Patients with light-chain immunoglobulin were given chemotherapy regimens,including bortezomib,dexamethasone,and cyclophosphamide.Patients with transthyretin protein type were treated with tafamidis.Conclusion When clinically suspected cardiac amyloidosis,endomyocardial biopsy should be performed as soon as possible to confirm diagnosis and classification and guide treatment.
Keywords：Endomyocardial biopsyCardiac amyloidosisClinical application
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1303-1305 )