Expressions and diagnostic value of serum Sestrin2 and neuregulin4 in patients with type 2 diabetes mellitus complicated by coronary heart disease

Hou Jiahui; Chen Meijuan; Zhao Xinlan

doi:10.3969/j.issn.1674-4055.2024.10.25

Abstract：Objective To investigate the clinical value of Sestrin2 and neuregulin4(Nrg-4)in patients with type 2 diabetes mellitus complicated by coronary heart disease(T2DM-CHD).Methods T2DM patients were chosen and divided,according to whether they had CHD or not,into CHD group and non-CHD group in People's Hospital of Hunan Province from Mar.2021 to Mar.2023.The levels of Sestrin2 and Nrg-4 were detected in 2 groups,and correlation among Sestrin2,Nrg-4 and clinical relative indexes were analyzed.The predictive value of Sestrin2 and Nrg-4 to T2DM-CHD was analyzed by using ROC curve.Results There were totally 102 T2DM patients chose(52 in CHD group and 50 in non-CHD group).The expressions of Sestrin2 and Nrg-4 were significantly lower in CHD group than those in non-CHD group(P＜0.05).The results of Pearson correlation analysis showed that levels of serum Sestrin2 and Nrg-4 were negatively correlated to diabetes course(r=-0.671,P＜0.001;r=-0.792,P＜0.001),fasting plasma glucose(FPG,r=-0.577,P＜0.001;r=-0.737,P＜0.001),glycated hemoglobin(HbA1c,r=-0.659,P＜0.001;r=-0.714,P＜0.001)and triglyceride(TG,r=-0.714,P＜0.001;r=-0.720,P＜0.001),and positively correlated to high-density lipoprotein-cholesterol(HDL-C,r=0.725,P＜0.001;r=0.688,P＜0.001).The results of Logistic regression analysis showed that Sestrin2(OR=0.73,95％CI:0.647～0.821,P＜0.001)and Nrg-4(OR=0.78,95％CI:0.718～0.844,P＜0.001)were protective factors for T2DM-CHD.The results of ROC curve analysis showed that AUC of Sestrin2 combined with Nrg-4 was 0.862,which was higher than that of single Sestrin2 or single Nrg-4 in predicting T2DM-CHD,and sensitivity was 86.00％and specificity was 80.77％.Conclusion The levels of serum Sestrin2 and Nrg-4 are correlated to CHD in T2DM patients,and Sestrin2 combined with Nrg-4 has a higher predictive value to T2DM-CHD.