Clinical significance of D-dimer in elderly patients with acute exacerbation of chronic obstructive pulmo-nary disease
Wang Jianguo
Zhang Dongyou
Li Ang
Ma Jinling
Bai Yongyi
Abstract：Objective To discuss the clinical significance of plasma D-dimer(D-D)level in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods The clinical materials from ACOPD patients(n=2206,aged from 80 to 98)were retrospectively analyzed in the First and Second Clinical Centers of Chinese PLA General Hospital from Dec.2008 to Dec.2020.The patients were followed up for investigate the incidence of mechanical ventilation(MV)and all-cause mortality within 30 d.The difference of plasma D-D were compared and statistically analyzed among groups.Results During follow-up for 30 d,there were 179 patients with MV treatment,and all-cause mortality was 6.2％(137/2206).The level of plasma D-D was significantly higher in non-survival group than that in survival group(P＜0.05),and was significantly higher in MV group than that in non-MV group.The results of multi-factor Logistic regression analysis showed that D-D was an influence factor for survival and MV requirement within 30 d.The results of Spearman correlation analysis showed that D-D level was positively correlated to level of C-reactive protein(P＜0.05).Conclusion During follow-up for 30 d,the higher D-D level is,the higher the MV requirement risk is,which indicates that D-D has some reference and guidance significance for prognosis in elderly AECOPD patients.
Keywords：Chronic obstructive pulmonary diseaseAgednessD-dimer
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1250-1252 )