Prediction analysis of H2FPEF score combined with NLR for no reflow/slow flow during percutaneous coronary intervention in patients with acute coronary syndrome
Zhang Yidan
Jiang Peng
Qin Xintong
Yin Qiuguo
Liu Shichao
Guo Ping
Jia Xingtai
Jian Liguo
Abstract：Objective To explore the relationship and predictive value of H2FPEF score combined with neutrophil-to-lymphocyte ratio(NLR)in patients with acute coronary syndrome(ACS)and no reflow/slow flow during percutaneous coronary intervention.Methods A total of 183 patients with acute coronary syndrome who underwent PCI were divided into the normal blood flow group(n=102)and the no reflow/slow flow group(n=81)according to their intraoperative coronary blood flow.The risk factors of the no reflow/slow flow phenomenon were analyzed and determined.The predictive value of the H2FPEF score,NLR and combined indexes on no reflow/slow flow was observed by the ROC curve.Result There were statistically significant differences in body mass index(BMI),hypertension history,lymphocyte count,neutrophil to lymphocyte ratio(NLR),H2FPEF score,pre-PCI TIMI blood flow level 0 between the normal flow group and the no reflow/slow flow group(P＜0.05).Multivariate regression analysis showed that,H2FPEF score and NLR were independent predictors of no reflow/slow flow occurrence.ROC curve analysis showed that the area of H2FPEF score under ROC curve was 0.728(95％CI:0.653～0.802),the sensitivity was 51.9％,the specificity was 88.2％,and the optimal critical value was 2.5.The area of NLR under ROC curve was 0.663(95％CI:0.585～0.741),the sensitivity was 81.5％,the specificity was 43.1％,and the optimal critical value was 2.31.The area under ROC curve of H2FPEF score combined with NLR(joint predictor)was 0.756(95％CI:0684～0.829),which was better than that of H2FPEF score alone.Conclusion Both H2FPEF score and NLR are independent predictors of no reflow/slow flow,and their combination can better predict no reflow/slow flow in patients with ACS during PCI than a single indicator.
Keywords：Acute coronary syndromeNo reflow/slow flowH2FPEF scoreNeutrophil-to-lymphocyte ratioPercutaneous coronary intervention
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1212-1216 )