Efficacy of microRNA-21 and microRNA-17-5p detections in heart failure diagnosis
Zhang Yumei
Liang Dong
Liu Hui
Zhao Xiwen
Abstract：Objective To discuss the efficacy of detections of microRNA-21(miR-21)and microRNA-17-5p(miR-17-5p)in heart failure diagnosis.Methods The patients with chronic heart failure(CHF,n=68)were chosen into CHF group and healthy controls(n=20)were chosen into control group from Sanya Central Hospital from Jan.2022 to Nov.2023,and their clinical materials were retrospectively studied.The levels of miR-21 and miR-17-5p,heart function indexes[left atrium(LA),left ventricle(LV),right atrium(RA),right ventricle(RV),ejection fraction(EF),interventricular septum(IVS)],and serum indexes[total cholesterol(TC),triglycerides(TG),alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB),blood urea nitrogen(BUN),creatinine(CR),uric acid(UA),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),white blood cell(WBC),hemoglobin(HGB),platelet(PLT)]were compared between 2 groups.The diagnostic value of miR-21 and miR-17-5p to CHF was analyzed by using ROC curve.Results The levels of miR-21 and miR-17-5p were higher in CHF group than those in control group(P＜0.05).The differences in LA,LV,RA,RV and EF had no statistical significance between 2 groups(P＞0.05),while IVS was higher in CHF group than that in control group(P＜0.05).The differences in TC,TG,LDL-C,HDL-C,WBC,PLT,ALT,AST,ALB,BUN,CR and UA had no statistical significance between 2 groups(P＞0.05),while HGB was higher in CHF group than that in control group(P＜0.05).The results of Pearson correlation analysis showed that miR-21 was positively correlated to miR-17-5p(P＜0.05).The results of ROC curve analysis showed that,in CHF diagnosis,AUC of miR-21 was 0.877,sensitivity was 77.1％and specificity was 70.8％,and AUC of miR-17-5p was 0.861,sensitivity was 90.0％and specificity was 90.0％.When miR-21 and miR-17-5p were incorporated into binary Logistic regression model,AUC of combined miR-21 and miR-17-5p in CHF diagnosis was 0.884,sensitivity was 79.2％and specificity was 90.0％.Conclusion The high expressions of serum miR-21 and miR-17-5p can be taken as effective indexes in CHF diagnosis,and there is a positive correlation between them
Keywords：Chronic heart failureMicroRNA-21MicroRNA-17-5p
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1190-1193 )