Correlation between serum ANGPTL3 level and lipid metabolism and the severity of coronary artery stenosis in patients with coronary artery disease
Wu Xingliang
Liu Chang
Zhu Qiuxia
Zhang Shiqin
Fang Zhao
Jiang Xuejun
Yi Xin
Abstract：Objective Angiopoietin-like protein 3(ANGPTL3)plays an important role in lipid metabolism and insulin resistance.In the present study,we aimed to observe circulating ANGPTL3 levels in patients with coronary artery disease(CAD),and analyze its correlation with lipid metabolism and the severity of coronary artery stenosis.Methods A total of 227 individuals,undergoing coronary angiography in the department of cardiology of our hospital from January 2019 to December 2019,were recruited in this study,and all of them were divided into 148 patients with CAD and 79 controls with non-CAD according to the results of coronary angiography.All patients'clinical and biochemical data were collected,including age,gender,medical history,body mass index(BMI),blood glucose,lipid and so on.The Gensini Score was used to evaluate the severity of CAD.Serum ANGPTL3 levels were measured by enzyme-linked immunosorbent assay(ELISA).Correlations between serum ANGPTL3 and clinical parameters such as lipid levels and the Gensini Score were all evaluated statistically.Results The serum ANGPTL3 level in the control group was 25.23(19.38-35.86)ng/ml,and the level in the CAD group was 28.05(19.50-40.16)ng/ml,which shows no significant difference.With an increasing number of coronary artery lesions,the serum ANGPTL3 level also gradually increased,and the 3-vessels group showed a higher ANGPTL3 level(P＜0.05).After dividing the serum ANGPTL3 level into tertiles,the high tertile group showed the highest prevalence of hyperlipidemia,TC,TG,Apo-B,and Gensini score(P＜0.05).In addition,univariate and multivariate linear regression demonstrated that serum ANGPTL3 levels were strongly associated with the Gensini score.Conclusions The elevated serum ANGPTL3 level is positively related to lipid metabolism in patients with CAD,and associated with the number of coronary artery lesions and severity of coronary artery stenosis,suggesting that detecting serum ANGPTL3 level has certain value and clinical significance for the evaluation of lipid metabolism disorder and the severity of coronary artery lesion in patients with CAD.
Keywords：Coronary artery diseaseANGPTL3Lipid metabolismLesion vessel numbersSeverity of stenosis
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1184-1189,1193 )