Levels of glycolipid metabolism,gasdermin D,interleukin-18 and risk warning model in elderly patients with coronary heart disease complicated by coronary artery calcification
Hai Ping
Zhang Qiyong
Mei Neng
Zhang Hong
Abstract：Objective To study the level changes of glycolipid metabolism,gasdermin D(GSDMD)and interleukin-18(IL-18)and risk warning model in elderly patients with coronary heart disease(CHD)complicated by coronary artery calcification(CAC).Methods CHD patients(n=350)were chosen from People's Hospital ofWuwei City from Dec.2022 to Oct.2023.After assessed CAC scores(CACs)by coronary CT angiography(CCTA),all patients were divided into CAC group(CACs≥ 10,n=280)and non-CAC group(CACs＜10,n=70).The baseline materials were compared in 2 groups.The independent risk factors of CAC were analyzed by using Logistic regression analysis model,and nomogram and ROC curve were established.Results There were statistical differences in age,fasting blood glucose(FBG),glycated hemoglobin(HbAlc),triglyceride(TG),low-density lipoprotein-cholesterol(LDL-C),insulin resistance index(IR),GSDMD and IL-18 between 2 groups(P＜0.05).The results of single-factor screening showed that age,FBG,TG,LDL-C,IR,GSDMD and IL-18 were possible influence factors of CAC in elderly CHD patients.The results of Logistic regression analysis showed that age ≥ 65 and higher blood sugar,TG,LDL-C,IR,GSDMD and IL-18 were risk factors for CAC occurrence in elderly CHD patients(P＜0.05).The results of nomogram model analysis showed that Bias-corrected predictive curve was basically aligns withIdeal line,which indicated that the model had a higher consistency between CAC and actual risk in risk predictions.The results of decision curve analysis showed that the model demonstrated a net benefit greater than 0 within the threshold probability range from 0.04 to 1.00,surpassed2 ineffective lines.The results of ROC curve analysis showed that,in combined index prediction,AUC was 0.888,which was larger than AUC of single index prediction with a higher discrimination for CAC in elderly CHD patients.Conclusion The risk factors for CAC occurrence include age ≥ 65 and higher blood sugar,TG,LDL-C,IR,GSDMD and IL-18 in in elderly CHD patients.
Keywords：Senile coronary heart diseaseCoronary artery calcificationGlycolipid metabolismGasdermin DInterleukin-18
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1119-1123 )