Relationship among expressions of miR-217 and miR-665,heart function and myocardial remodeling in patients with chronic heart failure
Duan Hongyu
Liu Dan
Wang Guoqiang
Abstract：Objective To analyze the relationship among serum expressions of serum microRNA-217(miR-217)and microRNA-665(miR-665),heart function and myocardial remodeling in patients with chronic heart failure(CHF).Methods CHF patients(n=60)were chosen into study group and healthy volunteers with normal physical examination(n=50)were chosen into control group from Baogang Hospital of Inner Mongolia from Apr.2022 to Apr.2023.The general materials were observed in 2 groups.The levels of miR-217 and miR-665,and indexes of heart function and myocardial remodeling were detected.The correlation among levels of miR-217 and miR-665,heart function and myocardial remodeling were analyzed.Results The expressions of miR-217,cardiac output(CO),left ventricular ejection fraction(LVEF)and left ventricular remodeling index(LVRI)decreased,and expressions of miR-665,left ventricular end-diastolic diameter(LVEDD),left atrial diameter(LAD)and left ventricular posterior wall thickness(LVPWT)increased in study group compared with control group(P＜0.05).The expressions of miR-217 and LVRI decreased,and miR-665,LVPWT and LVMI increased in patients with grades Ⅰ and Ⅱ of heart function classification compared with those with grades Ⅲ and Ⅳ(P＜0.05).The expressions of miR-217 and LVRI decreased,and miR-665,LVPWT and LVMI increased in patients with grades Ⅲ compared with those with grades Ⅳ(P＜0.05).The results of correlation analysis showed that miR-217 level was negatively correlated to CO,LVEF and LVRI,and positively correlated to LVEDD,LAD,LVPWT and LVMI,and miR-665 was positively correlated to CO,LVEF and LVRI,and negatively correlated to LVEDD,LAD,LVPWT and LVMI(P＜0.05).Conclusion The expression of serum miR-217 increases and miR-665 expression decreases in CHF patients,and expressions of miR-217 and miR-665 are correlated to heart function and myocardial remodeling.The detection of expressions of miR-217 and miR-665 can applied to assess CHF patients'condition.
Keywords：Chronic heart failureMicroRNA-217MicroRNA-665Heart functionMyocardial remodeling
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1112-1115 )