Clinical study on evaluating serum Tenascin-C as a biomarker in patients with acute aortic aneurysm/dissection

Chang Dongqing; Yeermaike·tangshahaer; Shao Jinjie; Zhang Xiaomeng; MaiMaitiaili·Aizezi

doi:10.3969/j.issn.1674-4055.2024.09.16

Abstract：Objective Tenascin-C(TNC)is associated with poor prognosis of cardiovascular disease and the occurrence of major cardiovascular events.Methods Retrospective inclusion of data from 120 AAD patients(AAD group)(Stanford type A or B,all admitted within 24 hours of sudden pain symptoms)who received treatment at the Department of Cardiology and Extravascular Medicine Diagnosis and Treatment Center of Xinjiang Uygur Autonomous Region People's Hospital from May 2021 to March 2022.All patients were admitted within 24 hours after sudden pain symptoms.In addition,107 patients with carotid artery stenosis(CAS)and 120 healthy volunteers were selected as CAS group and normal control group.The serum TNC level of AAD group was detected before surgery and at 1,3,7 and 14 days after emergency thoracotomy surgery,and the serum TNC level of CAS group and normal control group were compared.The primary endpoint was short-term survival outcomes at 60 days after surgery.Results Compared with the normal control group,patients in the AAD group showed a significant increase in perioperative serum TNC levels(P＜0.001).Moreover,the serum TNC level of Stanford type A patients at admission was higher than that of type B(P＜0.05).The serum TNC levels of patients in the AAD group significantly decreased on 3rd day after surgery compared to perioperative TNC level(P＜0.05),and there were statistically significant differences on 3rd day,7th day,and 14th day after surgery(P＜0.05).Moreover,there was no statistically significant difference in serum TNC levels between the 14th day after surgery and the normal control group(P=0.383).Compared with the normal control group,the serum TNC levels of patients in the CAS group significantly increased(P＜0.001),and was positively correlated with the degree of carotid artery stenosis(r=0.279,P=0.004).The area under the curve(AUC)of perioperative serum TNC for predicting AAD was 0.731,and the AUC for predicting CAS was 0.671.Most importantly,serum TNC could effectively distinguish between AAD and CAS patients,with an AUC of 0.816.23 AAD patients died within 60 days after surgery.Stratified according to the threshold value of ROC curve of perioperative serum TNC level(172.74 pg/mL),the short term survival rate of AAD patients was related to perioperative serum TNC level(log rank=3.706,P=0.047).Conclusion Serum TNC level can serve as a potential diagnostic and prognostic biomarker for AAD,and it is recommended to comprehensively evaluate this indicator in clinical practice to improve prognosis.