Relationship between serum S100A8/A9 andmajor adverse cardiovascular eventsin patients with acute myocardial infarctionafter percutaneous coronary intervention
Zhang Weijian
Liu Yichen
Yan Yao
Zhao Chuanyan
Abstract：Objective To investigate the predictive value of serum S100A8/A9 to major adverse cardiovascular events(MACE)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods AMI patients undergone PCI(n=193)were chosen into AMI group from School of Clinical Medicine of Shandong Second Medical University from Mar.2019 to Dec.2020.According to whether MACE occurred within 1 month after PCI or not,the AMI group was divided into MACE group(n=25)and non-MACE group(n=168),and healthy volunteers with physical examination(n=201)were chosen into control during the same period.The level of serum S100A8/A9 was detected by using ELISA,and influence factors for MACE occurrence within 1 month after PCI were analyzed.The predictive value of S100A8/A9 to MACE occurrence after PCI was reviewed by using ROC curve analysis.The influence factors for MACE occurrence were analysis by using Logistic regression analysis.Results The level of S100A8/A9 increased significantly in AMI group compared with control group(P＜0.05).The number of AMI patients complicated by hyperlipidemia and coronary heart disease(CHD),levels of fasting blood glucose(FBG),triglyceride(TG)and total cholesterol(TC),number of implanted stents ≥ 2,stent diameter≥ 3 mm and heart rate(HR)were all higher in MACE group than those in non-MACE group(P＜0.05).The level of S100A8/A9 increased significantly in MACE group than that in non-MACE group(P＜0.05).The results of ROC curve analysis showed that the review value of S100A8/A9 was 0.699,and when S100A8/A9＞3.158 mg/ml,it could predict MACE after PCI,and sensitivity was 65.7％and specificity was 65.9％.The results of Logistic regression analysis showed that S100A8/A9 was a significant risk factor for MACE occurrence in AMI patients.Conclusion The level of serum S100A8/A9 is correlated to MACE occurrence,and detection of S100A8/A9may help determine MACE status in AMI patients after PCI.
Keywords：Acute myocardial infarctionPercutaneous coronary interventionMajor adverse cardiovascular events
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1092-1095 )