Relationship between extracellular volume acquired by cardiac magnetic resonance and microvascular obstruction
Zhang Zeqing
Chen Qing
Zhao Xinliang
Yue Peng
Yang Yu
Chen Wensu
Abstract：Objective To investigate the relationship between extracellular volume(ECV)acquired by cardiac magnetic resonance(CMR)and microvascular obstruction(MVO)in patients with ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods STEMI patients undergone CMR examination and PCI(n=308)were retrospectively chosen from Jan.2022 to Oct.2023.All patients were divided,according to whether they had MVO,into MVO group and control group.The clinical baseline materials were compared between 2 groups.The influence factors for MVO were studied by using single-factor and multi-factor Logistic regression analyses in STEMI after PCI.The relevant ROC curve was drawn for studying the predictive value of ECV,high sensitivity cardiac troponin T(hs-cTnT),TIMIflow grades and left ventricular ejection fraction(LVEF)to MVO occurrence after PCI.According to ECVcutoff value by ROC curve analysis,the patients were divided into low-ECV group and high-ECV group.Results TIMIflow grades,peak value of N-terminal pro-brain natriuretic peptide(NT-proBNP)and hs-cTnT,LVEF and ECV at siteof myocardial infarction were independent risk factors for MVO(P＜0.01).In prediction of MVO by ECV,AUC of ROC curve was 0.687(95％CI:0.628～0.746,P＜0.001),sensitivity was 84.9％and specificity was 49.4％.The level of hs-cTnT was higher and LVEF was lower in high-ECV group than those in low-ECV group(P＜0.01).Conclusion ECV at site of myocardial infarction is an independent risk factor for MVO occurrence.
Keywords：ST-segment elevation myocardial infarctionPercutaneous coronary interventionExtracellular volumeMicrovascular obstruction
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1075-1079,1095 )