Gender differences and diagnostic value of biomarkers in patients with essential hypertension complicat-ed by depression
Li Guo
Zhang Lijun
Liu Meiyan
Abstract：Objective To investigate the gender differences and diagnostic value of biomarkers in patients with essential hypertension(EH)complicated by depression.Methods EH patients were chosen from Beijing Anzhen Hospital affiliated to Capital Medical University from July 1,2019 to Mar.31,2021.Patient Health Questionnaire-9 Items(PHQ-9)was used to assess depression status in patients in nearly 2 weeks.The fasting blood samples were collected for examinations of blood routine,blood coagulation and blood biochemistry.The statistical methods were used through SPSS software,including t test,rank sum test,Logistic regression analysis and ROC curve analysis.The patients were divided into groups according to depression status,and also divided into groups according to gender.Results There were totally 898 EH patients included,among them,266 with EH complicated by depression and 632 with EH without depression.The incidence of depression was 29.6％.In analysis according to depression group and non-depression group,the results of ROC curve analysis showed that white blood cell count(WBC,AUC=0.552,P=0.034,95％CI:0.503～0.600)and neutrophile(NE,AUC=0.555,P=0.024,95％CI:0.507～0.603)had some diagnostic value to depression in EH patients.In analysis according to male group and female group,the results showed that incidence of depression was 27.2％in male EH patients and 33.4％in female EH patients.The indexes with diagnostic value to depression in male EH patients included total cholesterol(TC),triglyceride(TG),small and dense low-density lipoprotein cholesterol(sdLDL-C),lipoprotein a(Lpa),(AUC=0.769,P=0.003,95％CI:0.623～0.914),and TC,TG,HDL-C,LDL-C,sdLDL,Lps,free fatty acid(FFA),(AUC=0.807,P=0.001,95％CI:0.674～0.940).The indexes with diagnostic value to depression in female EH patients included C1q,hs-CRP,WBC,NE％,Lymphocyte(LYM％),(AUC=0.852,P=0.005,95％CI:0.697～1.000).Conclusion The depression status can be found early with biomarkers in EH patients.Meanwhile,lipid-related biomarkers may be beneficial for predicting depression in male EH patients,and immune-inflammatory factors may be beneficial for predicting depression in female EH patients.
Keywords：HypertensionDepressionBiomarkersGender differences
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 1048-1055 )