Model establishment and review of bilirubin and lipid composite indexes in predicting risk of essential hypertension
Zhang Yu
Gao Ying
Li Yanpeng
Song Xingming
Li Ning
Luo Ruqiao
PalidaAbulaiti
Abstract：Objective To discuss the correlation between bilirubin and lipid composite indexes and essential hypertension(EH).Methods A total of 2795 patients were chosen from the Third Departments of Comprehensive Internal Medicine in the First Affiliated Hospital of Xinjiang Medical University from June 2022 to June 2023.All patients were divided,according to EH occurrence status,into EH group(n=1163)and non-EH group(n=1213).The risk factors of EH were analyzed by using multi-factor Logistic regression analysis.On the above base,a predictive model of EH onset was established and a column chart was drawn.The bilirubin and lipid composite indexes were analyzed in subgroups.Results Between EH group and non-EH group,age,nationality,ethnicity,body mass index(BMI),hemoglobin(HGB),platelet(PLT),fibrinogen(FIB),serum creatinine(SCr),uric acid(UA),density lipoproteincholesterol,HDL-C)、fasting blood sugar(FBG),triglyceride(TG),total cholesterol(TC),low-density lipoproteincholesterol(LDL-C),high-density lipoproteincholesterol(HDL-C),apolipoprotein B(ApoB),total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL),Index1[TC/(HDL-C+TBIL)]and Index2[LDL/(HDL-C+TBIL)]had statistical differences(all P＜0.05).The results of Logistic analysis showed that age,BMI,HGB,FIB,TG,DBIL,Index1 and Index2 were risk factors for EH occurrence.All risk factors were imported to predictive model and ROC curve of the model was drawn,and AUC of the model was 0.780(95％CI:0.762-0.799,P＜0.05).Under a stratificationof 24-28 kg/m2ofBMI,for each SD increase in Index2,the risk of EH occurrence increased by 43％,41.9％,and 61.2％,respectively,in model 1,model 2,and model 3.Under a stratification＞28 kg/m2 of BMI,for each SD increase in Index1,the risk of EH occurrence was 2.239 times,2.263 times and 1.931 times,respectively,in model 1,model 2,and model 3.Conclusion The bilirubin and lipid composite indexes is closely correlated to EH occurrence,and the column chart model for predicting EH risk has a higher efficacy in clinical practice.
Keywords：HypertensionBilirubin and lipid composite indexesRisk prediction
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 977-982 )