Value of Holter and levels of serum forkhead box protein O3 and thioredoxin interacting protein in di-agnosing chronic heart failure
Wei Xiao
Zhan Jiang
He Dinghua
Chen Yan
Wan Xiaoxia
Abstract：Objective To investigate the expressions of serum forkhead box protein O3(FOXO3)and thioredoxin interacting protein(TXNIP)and value of Holter combined with FOXO3 and TXNIP in diagnosis of chronic heart failure(CHF).Methods CHF patients were prospectively chosen into CHF group and healthy controls were chosen into control group(each n=68)from Central Hospital of Ezhou City of Hubei Province from June 2022 to Jan.2023.The levels of FOXO3 and TXNIP were compared between 2 groups.The diagnostic efficacy of FOXO3 and TXNIP in CHF diagnosis was analyzed by using ROC curve.The diagnosis of Holter combined with FOXO3 and TXNIP to CHF was analyzed by using four-grid table method.Results The expression of FOXO3(1.28±0.34)ng/ml was lower in CHF group than that in control group(1.73±0.36)ng/ml(P＜0.05),and expression of TXNIP(126.42±12.98)pg/ml was higher in CHF group than that in control group(108.86±12.73)pg/ml(P＜0.05).The accuracy rate of Holter combined with FOXO3 and TXNIP was 94.85％,sensitivity was 97.06％and specificity was 92.65％in diagnosing CHF.The accuracy rate and sensitivity of Holter combined with FOXO3 and TXNIP were higher than those of Holter,FOXO3 or TXNIP alone(P＜0.05).Conclusion The expression of serum FOXO3 decreases and expression of serum TXNIP increases in CHF patients.Holter combined with FOXO3 and TXNIP has a higher diagnostic value to CHF.
Keywords：Chronic heart failureHolterForkhead box protein O3Thioredoxin interacting protein
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 969-971,991 )