Clinical predictive value of non-traditional blood lipid parameters toseverity of coronary artery lesions in elderly patients with coronary heart disease
Yu Qian
Chen Yinyin
Zhao Qing
Zhao Linya
Abstract：Objective To analyze the clinical predictive value of non-traditional blood lipid parameters toseverity of coronary artery lesions in elderly patients with coronary heart disease(CHD).Methods Elderly patients(n=185)received coronary angiography(CAG)were chosen from Department of Geriatrics in the Affiliated Hospital of Hebei University from Mar.2021 to Mar.2023.The patients were divided,according to CAG results,into CHD group(n=104)and non-CHD group(n=81),and CHD group was divided,according to Gensini scores,into mild lesion subgroup(scores ≤24,n=34),moderate lesion subgroup(scores=25-49,n=37)and severe lesion subgroup(scores≥50,n=33).The blood samples were collected to detect non-traditional blood lipid parameters including small and dense low-density lipoprotein cholesterol(sdLDL-C),apolipoprotein B(ApoB),non-high-density lipoprotein-cholesterol(non-HDL-C)and lipoproteina(Lpa)in all groups.The levels of non-traditional blood lipid parameters were compared between non-CHD group and CHD group,and relationship among the parameters and severity of coronary artery lesions was analyzed.The diagnostic value of non-traditional blood lipid parameters to CHD was analyzed by using ROC curve.Results The levels of sdLDL-C,ApoB,Lp a and non-HDL-C were higher in CHD group than those in non-CHD group(P＜0.05).The differences in levels of sdLDL-C,ApoB,Lp a and non-HDL-C had statistical significance among subgroups(P＜0.05),and the levels were higher in severe lesion subgroup than those in mild lesion subgroup and moderate lesion subgroup(P＜0.05).The results of correlation analysis showed that the levels of sdLDL-C,ApoB,Lp a and non-HDL-C were positively correlated to severity of coronary artery lesions(P＜0.05).The results of ROC curve analysis showed that sdLDL-C(AUC=0.835,95％CI:0.733～0.936,P＜0.001),ApoB(AUC=0.754,95％CI:0.651～0.857,P＜0.001),Lp a(AUC=0.949,95％CI:0.911～0.987,P＜0.001)and non-HDL-C(AUC=0.879.95％CI:0.814～0.943,P＜0.001)had higher predictive value to severe CHD.Conclusion The levels of sdLDL-C,ApoB,Lp a and non-HDL-C are closely correlated to CHD in elderly patients,and they have higher predictive value to severity of coronary artery lesions.
Keywords：Coronary heart diseaseApolipoprotein BLipoproteinaElderly
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 806-809 )