The evaluation value of novel inflammatory index in the severity and adverse prognosis after intervention in patients with ST segment elevation myocardial infarction
Yin Jian
Wei Xiao
Yan Qingkai
Liu Jie
Deng Zixiang
Liu Dawei
Tu Zhitao
Luo Wenping
Abstract：Objective To assess the the prognostic and diagnostic value of systemic immune-inflammation index(SII)in evaluating coronary artery disease severity and adverse outcomes following percutaneous coronary intervention(PCI)in patients with ST-segment Elevation Myocardial Infarction(STEMI).Methods From January 2018 to March 2020,272 STEMI patients who underwent PCI during their hospitalization at our institution were selected.These patients were divided into two groups based on the median SII value of 621.38:a low SII group(SII＜621.38)and a high SII group(SII≥621.38)Clinical data were collected,and the relationship between SII levels and adverse post-intervention outcomes in STEMI patients was analyzed.Results Patients in the high SII group were found to be older and to have higher heart rates and lower blood pressures.They also had a greater prevalence of hypertension and type 2 diabetes,as well as a higher incidence of Major Adverse Cardiovascular Events(MACE)(P<0.05).Compared to the low SII group,the high SII group exhibited elevated levels of white blood cell,neutrophils,platelets,Gensini score,GRACE score,high-sensitivity C-reactive protein(hs-CRP),Glu,left ventricular ejection fraction(LVEF),and creatinine,with a reduction in lymphocyte counts(P<0.05).Correlation analyses demonstrated a significant positive relationship between SII andboth Gensini and GRACE scores(P<0.05).Kaplan-Meier analysis showed that the rate of MACE occurrence was significantly higher in the high SII group(P<0.05).The combination of SII and GRACE scores has a higher predictive value for MACE after PCI in STEMI patients compared to the two alone,with an AUC of 0.935.Conclusion The combination of SII and GRACE score has good predictive value in evaluating the degree and adverse prognosis in patients with STEMI.
Keywords：ST segment elevation myocardial infarctionSystemic immune-inflammation indexGRACE score
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 619-621,630 )