Analysis of plasma D-dimer levels and anticoagulant therapy effects in elderly patients with thrombotic diseases
Wu Yuntao
Chen Yanmei
Liu Lixin
Yao Lu
Tian Guoxiang
Huang Yonghua
Abstract：Objective The purpose of this study is to explore the plasma D-dimer(DD)levels and anticoagulant therapy effects in elderly patients with thrombotic diseases.Method Elderly patients admitted to the Geriatrics Department of the Seventh Medical Center of the General Hospital of the People's Liberation Army from January 2014 to December 2022 were collected.They were divided into an observation group(180 cases,with thrombotic disease)and a control group(182 cases,without thrombotic disease)based on whether acute thrombotic disease was present.Compare the DD levels and positive rates between two groups of patients,and analyze the plasma DD levels and positive rates of patients in different subgroups of thrombotic diseases in the observation group.Results The average level of plasma DD in the observation group was significantly higher than that in the control group[(6.72±0.51)mg/L vs.(0.21±0.08)mg/L,P<0.01)].The positive detection rate of plasma DD in the observation group was significantly higher than that in the control group(100.0%vs.6.59%),(P<0.01).The average plasma DD levels in the subgroups of acute pulmonary embolism and acute lower limb deep vein thrombosis were significantly higher than those in the subgroups of acute myocardial infarction and acute cerebral infarction(P<0.05),while there was no significant difference between the subgroups of acute lower limb deep vein thrombosis and acute pulmonary embolism(P>0.05).There was no significant statistical difference in the average level of DD between the acute myocardial infarction group and the acute cerebral infarction group(P>0.05).One week after initiating or strengthening anticoagulation,the plasma DD level was significantly reduced compared to when thrombosis occurred(P<0.01).Compared with the observation group,there was no statistically significant difference in the plasma DD positive rate(P>0.05).Conclusion DD is a specific indicator of thrombotic disease and hypercoagulable state in elderly patients.Routine examination upon admission can timely detect the presence of thrombosis or hypercoagulable state,which has important guiding significance for guiding the diagnosis of thrombotic disease in clinical practice,initiating anticoagulation,and strengthening anticoagulant treatment.
Keywords：Advanced ageD-dimerThrombotic diseasesAnticoagulation therapy
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 583-585,598 )