Clinical risk factors in patients with severe carotid artery stenosis complicated by coronary artery disease
Xing Haoran
Zhang Min
Zheng Tiejin
Zhang Nan
Fan Chengzhe
Zuo Huijuan
Song Xiantao
Zhang Hongjia
Abstract：Objective To study the clinical risk factors in patients with severe carotid artery stenosis(SCAS)complicated by coronary artery disease(CHD).Methods The patients received cerebral angiography with at least one vessel of SCAS were retrospectively chosen from Department of Cardiovascular Medicine,Department of Cerebrovascular Disease and Department of Neurosurgery in Beijing Anzhen Hospital,Capital Medical University from Jan.1,2016 to Sept.30,2021.All patients were divided,according to whether complicated by CHD or not,into SCAS+CHD group(n=654)and SCAS group(n=464).The differences in clinical risk factors and biochemical indexes were compared between 2 groups.The clinical risk factors and biochemical indexes were analyzed in patients with SCAS complicated by CHD.Results There were totally 1118 patients with SCAS and among them there were 654(58.5%)complicated by CHD.The percentages of hypertension,diabetes,complicated severe vertebral/subclavian artery stenosis,and higher levels of lipoprotein(a)[Lp(a)]and glycated hemoglobin(HbAlc)were higher in SCAS+CHD group than those in SCAS group(P<0.05).The results of multi-factor regression analysis showed that age,male,hypertension,severe vertebral/subclavian artery stenosis,higher Lp(a)and lower high-density lipoprotein-cholesterol(HDL-C)were independent risk factors of SCAS complicated by CHD(P<0.05).The risk factor was mainly hypertension in group aged under 60,and were male,severe vertebral/subclavian artery stenosis,higher Lp(a)and lower HDL-C in group aged over 60.As increase of cumulative risk factors,odds ratio(OR)for SCAS complicated by CHD increased(P<0.05).Conclusion Age,male,hypertension,severe vertebral/subclavian/cerebral artery stenosis,higher Lp(a)and lower HDL-C are independent risk factors of SCAS complicated by CHD.There is difference in risk factor distribution between group aged under 60 and group aged over 60.The risk of SCAS complicated by CHD will increase with the accumulation of risk factors.
Keywords：Coronary artery diseaseSevere carotid artery stenosisRisk factors
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 577-582 )