Significance of NOD-like receptor thermal protein domain associated protein 3 and soluble vascular cell adhesion molecules-1 levels to restenosis in patients with lower extremity vascular disease of type 2 diabe-tes mellitus after interventional therapy
Zhang Jiguang
Yang Xianda
Jin Kaixing
Abstract：Objective To investigate the significance of levels of NOD-like receptor thermal protein domain associated protein 3(NLRP3)and soluble vascular cell adhesion molecules-1(sVCAM-1)to restenosis in patients with lower extremity vascular disease of type 2 diabetes mellitus(T2DM)after interventional therapy.Methods The clinical materials were retrospectively analyzed in patients with lower extremity vascular disease of T2DM(n=104)undergone successful vascular interventional therapy in Department of Vascular Intervention of Handan Central Hospital of Hebei Province from Jan.2022 to Jan 2023.All patients were divided,according to restenosis occurrence after the intervention,into restenosis group(n=20)and non-restenosis group(n=84).The general materials and levels of NLRP3 and sVCAM-1 after the intervention for 24 h were compared between 2 groups.The influence factors of restenosis were analyzed by using multi-factor Logistic regression model.The predictive value of NLRP3 and sVCAM-1 to restenosis was analyzed after established ROC curve.Results The course of T2DM and length of lower extremity arterial lesions were longer in restenosis group than those in non-restenosis group.The proportions of phase IV of Fontaine staging and complete occlusion of lower extremity arteries,and levels of serum glycated hemoglobin(HbAlc),high sensitivity C-reactive protein(hs-CRP),NLRP3 and sVCAM-1 were higher(P<0.05)in restenosis group.The results of multi-factor Logistic regression analysis showed that complete occlusion of lower extremity arteries,length of lower extremity arterial lesions,HbA1c,NLRP3 and sVCAM-1 were influence factors of restenosis in patients with lower extremity vascular disease of T2DM after the intervention(P<0.05).The results of ROC curve analysis showed that the predictive value of NLRP3 combined with sVCAM-1 in detecting restenosis occurrence was higher,and sensitivity was 95.00%,specificity was 71.43%and AUC was 0.929.Conclusion The higher expressions of serum NLRP3 and sVCAM-1 are risk factors of restenosis,and NLRP3 combined with sVCAM-1 can improve the accuracy in predicting restenosis in patients with lower extremity vascular disease of T2DM after the intervention.
Keywords：Type 2 diabetes mellitusLower extremity vascular diseaseInterventionNOD-like receptor thermal protein domain associated protein 3Soluble vascular cell adhesion molecules-1
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 573-576,582 )