Relationship between warfarin administration guided by inflammation genotypes and curative effect of mechanical heart valve replacement surgery
Han Xiaohu
Li Ruzheng
Sun Hening
Abstract：Objective To discuss the relationship between warfarin administration guided by inflammation genotypes and curative effect of mechanical heart valve replacement surgery.Methods The patients(n=91)undergone heart valve replacement surgery and scheduled to receive warfarin anticoagulant therapy were chosen from Department of Cardiac Surgery in People's Hospital of Hainan Province from Jan.2020 to July 2023.All patients were divided,by using stratified block randomized,into inflammation genotype group and non-inflammation genotype group based on the genotypes ofrecombinant cytochrome P450 2C9(CYP2C9)and vitamin K epoxide reductase complex subunit 1(VKORC1).The primary outcome was percentage of time in therapeutic range(pTTR),including the first week after beginning warfarin therapy,during hospitalization and up to the first outpatient visit.Results There were 42 patients in inflammation genotype group and 49 in non-inflammation genotype group.There was no significant difference in genotype frequency between in flammation genotype group and non-inflammation genotype group(P>0.05).The value of pTTR had an ascending trend in inflammation genotype group compared with non-inflammation genotype group,but there was no statistical significance(P>0.05).The subgroup analysis showed that value of pTTR increased significantly during the first week after beginning warfarin therapy,during hospitalization and up to the first outpatient visit in inflammation genotype group compared with non-inflammation genotype group in aortic valve replacement subgroup(P<0.05).The value of pTTR had no significant difference between inflammation genotype group and non-inflammation genotype group in mitral valve replacement subgroupand other valve replacement subgroups(P>0.05).Conclusion The warfarin administrationguided by inflammation genotypes may be beneficial to patients undergone mechanical aortic valve replacement.
Keywords：Inflammation genotypesWarfarinMechanicalaortic valve replacementCurative effect
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 569-572 )