Clinical value of platelet derived growth factor combined with brain natriuretic peptide in predicting new-onset atrial fibrillation after off-pump coronary artery bypass grafting
Jiang Lijie
Liu Zhaoxun
Zhang Xinhua
Zhao Jingyu
Abstract：Objective To investigate the clinical value of platelet derived growth factor(PDGF)combined with brain natriuretic peptide(BNP)in predicting new-onset atrial fibrillation(AF)in patients undergone off-pump coronary artery bypass grafting(OPCABG).Methods The patients(n=197)undergone OPCABG were chosen from Department of Cardiovascular Surgery in Handan Central Hospital from Jan.2021 to Jan.2023.The levels of serum PDGF(enzyme-linked immunosorbent assay)and BNP(radioimmunoassay)were detected in all patients before the operation.The patients were divided,according to whether they had AF or not during hospitalization,into new-onset AF group(n=37)and non-new-onset AF group(n=160).The predictive value of PDGF and BNP to new-onset AF was reviewed by using ROC curve analysis in patients after OPCABG.The influence factors of new-onset AF were discussed by using multi-factor Logistic regression analysis in patients after OPCABG.Results The levels of serum BNP and PDGF were higher in new-onset AF group than those in non-new-onset AF group(P<0.05).Age,right coronary artery stenosis rate,assisted ratio of postoperative intra-aortic balloon pumps(IABP),mechanical ventilation(MV)time,fasting plasma glucose(FPG)and left atrial volume index(LAVI)were higher,and left ventricular ejection fraction(LVEF)was lower in new-onset AF group than those in non-new-onset AF group(P<0.05).The results of multi-factor Logistic regression analysis showed that proximal right coronary artery stenosis≥75%(OR=2.090,95%CI:1.495～2.922),BNP≥287.64 pg/ml(OR=2.746,95%CI:1.798～4.193)and PDGF≥398.57 μg/L(OR=2.601,95%CI:1.765～3.835)were influence factors of postoperative new-onset AF after OPCABG.The AUC of BNP was 0.781(95%CI:0.756～0.818),AUC of PDGF was 0.825(95%CI:0.797～0.861)and AUC of BNPcombined with PDGF was 0.901(95%CI:0.874～0.935)in predicting postoperative new-onset AF after OPCABG.Conclusion The levels of serum PDGF and BNP increase in patients with new-onset AF after OPCABG,and they can be taken as the predictive indicators for new-onset AF after OPCABG.The predictive efficacy of PDGF combined with BNP is higher,which can provide basis for early treatment in clinical practice.
Keywords：Platelet derived growth factorBrain natriuretic peptideOff-pump coronary artery bypass graftingAtrial fibrillationPredictive value
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 564-568 )