Correlation between myocardial reperfusion injury and ERK/MAPK signaling pathway in elderly patients with coronary heart disease after PCI
Yuan Xiaoli
Wang Dan
Jing Haiyun
Xing Ruixing
Yang Dongwei
Abstract：Objective To investigate the influencing factors of myocardial reperfusion injury in elderly patients with coronary heart disease after percutaneous coronary intervention(PCI)and its correlation with the activation of extracellular signal-regulated kinase/mitogen-activated protein kinase(ERK/MAPK)signaling pathway.Methods Ninety-two elderly patients with coronary heart disease who underwent PCI in the Department of Cardiovascular Medicine of Zhengzhou University Affiliated Zhengzhou Central Hospital from March 2020 to December 2022 were selected as the research subjects.Real-time quantitative PCR was used to detect the expression of ERK and p38-MAPK mRNA expression in patients before surgery and assess myocardial reperfusion injury after PCI surgery.This study also analyzed the influencing factors and their relationship with the ERK/MAPK signaling pathway indicators.Results In 92 patients,20 cases(21.74%)experienced myocardial reperfusion injury after PCI surgery(injury group,n=20).The proportion of patients in the injury group with pre-PCI blood flow grade≤2 and Killip class≥2 was significantly higher than in the non-injury group.Preoperative serum levels of ERK and p38-MAPK mRNA were higher in the injury group compared to the non-injury group,with statistically significant differences(P<0.05).Multivariable regression analysis indicated that pre-PCI blood flow grade≤2,Killip class≥2,and elevated serum levels of ERK and p38-MAPK are influencing factors for myocardial reperfusion injury after PCI in elderly patients with coronary artery disease(P<0.05).Conclusion In addition to blood flow grade and Killip grade,high expression of ERK/MAPK signaling pathway before operation can increase the risk of myocardial reperfusion injury in elderly patients with coronary heart disease after PCI,suggesting close clinical monitoring to identify myocardial reperfusion injury as early as possible and take targeted intervention measures.
Keywords：Coronary heart diseasePercutaneous coronary interventionMyocardial reperfusion injuryERK/MAPK signaling pathway
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 561-563,568 )