Association between leukocyte telomere length and the risk of aortic aneurysm:A bidirectional two-sam-ple Mendelian randomization study
Fan Qinglu
Nie Zhihao
Xie Songping
Abstract：Objective To investigate the potential causal relationship of leukocyte telomere length(LTL)with the risk of aortic aneurysm(AA)using a bidirectional two-sample Mendelian randomization(MR)study.Methods Based on latest public genome-wide association study(GWAS)databases of LTL and AA,genetic variants associated with the LTL and AA were selected as instrumental variables(IV)to perform a bidirectional two-sample MR study.The causal relationship of LTL with AA risk was mainly assessed by inverse-variance weighting(IVW)method.Heterogeneity was analyzed by the Cochran's Q test,the MR-Egger intercept was used to explore the potential pleiotropy of instrumental variables,and Leave-one-out(LOO)was used as sensitivity analysis.Results Genetically predicted that longer LTL was causally associated with the risk of AA,and LOO test showed that the results have robustness,while AA was not causally associated with the risk of LTL.Conclusion The MR study result indicated that longer LTL is protective against AA,hence,LTL monitoring of patients will be helpful for the early detection and prevention of AA.
Keywords：Leukocyte telomere lengthAortic aneurysmMendelian randomizationCausal relationship
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 513-516 )