Correlation among non-high-density lipoprotein-cholesterol,apolipoprotein B/apolipoprotein A1 ratio and incipient acute myocardial infarction
Tu Shiqin
Gao Lingyun
Abstract：Objective To investigate the clinical characteristics of patients with incipient acute myocardial infarction(AMI)and different levels of non-high-density lipoprotein cholesterol(non-HDL-C),and discuss the correlation among,apolipoprotein B/apolipoprotein A1 ratio(ApoB/ApoA1),non-HDL-C and severity of coronary artery lesions.Methods The patients with incipient AMI undergone coronary angiography(CAG)examination(n=410)were chosen from Department of Cardiovascular Medicine in the First Affiliated Hospital of Chongqing Medical University from Dec.2021 to Apr.2023.Apo B/Apo A1 and non-HDL-C were calculated,and the patients were divided,according to non-HDL-C tertiles,into low non-HDL-C group(≤ 2.89 mmol/L),mediate non-HDL-C group(2.9～4.16 mmol/L)and high non-HDL-C group(≥4.17 mmol/L).The differences in clinical materials and coronary lesion features were compared among 3 groups.The influence of non-HDL-C level,and Apo B/Apo A1 on severity of coronary artery lesions were analyzed by using Spearman rank correlation and binary Logistic regression analysis.Results The patients were younger in mediate non-HDL-C group and high non-HDL-C group than those in low non-HDL-C group(P＜0.05).The levels of body mass index(BMI),triglyceride(TG),HDL-C,ApoB,ApoA1,ApoB/ApoA1,albumin(ALB),gamma-glutamyltransferase(GGT)and uric acid(UA)were higher in high non-HDL-C group than those in other 2 groups(P＜0.05).The differences in lesions of left anterior descending branch(LAD),left circumflex branch and multiple vessels,and Gensini scores had statistical significance among 3 groups(P＜0.05).The Results of biased correlation analysis showed that Apo B/Apo A1,non-HDL-C,multiple vessel lesions and Gensini scores had positive correlation(P＜0.05).The Results of multi-factor binary Logistic regression analysis showed that ApoB/ApoA1(OR=3.149,95％CI:1.209～8.201,P=0.019)and Non-HDL-C ≥ 4.17 mmol/L(OR=4.199,95％CI:1.524～11.565,P=0.006)were independent risk factors for multiple vessel lesions.Conclusion The clinical indexes of ApoB/ApoA1 and non-HDL-C should be paid more attention to in younger patients with incipient AMI and risk factors of coronary artery lesions or coronary heart disease,meanwhile strict controlling of non-HDL-C is a potential lipid-lowering target in AMI patients.
Keywords：Non-high-density lipoprotein-cholesterolAcute myocardial infarctionMulti-vessel lesions
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 436-440 )