Correlation between apolipoprotein A-1 expression and major adverse cardiovascular events of acuter myocardial infarction treated with recombinant human brain natriuretic peptide
Wang Zixuan
Wang Xu
Dong Huanle
Abstract：Objective To study the correlation between expression of apolipoprotein A-1(ApoA-1)and major adverse cardiovascular events(MACE)of acuter myocardial infarction(AMI)treated with recombinant human brain natriuretic peptide(rhBNP).Methods AMI patients(n=132)treated with rhBNP were retrospectively analyzed in Department of Cardiology in the Second Affiliated Hospital of Shaanxi University of Chinese Medicine from Mar.2021 to Feb.2023,and the patients were divided,according to whether MACE occurred or not,into MACE group(n=19)and non-MACE group(n=113).The correlation among ApoA-1 expression and 4 outcomes including stroke,cardiac death,relapsed myocardial infarction and angina pectoris(AP)was analyzed.The incidence of MACE was analyzed by using single-factor and multi-factor Logistic regression analyses in AMI patients after rhBNP treatment.The correlation between ApoA-1 expression and MACE after rhBNP treatment was studied.Results The level of ApoA-1 expression was higher in MACE group than that in non-MACE group(P<0.05).The levels of left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),serum creatinine(SCr)and blood urea nitrogen(BUN)decreased,and levels of left ventricular ejection fraction(LVEF)and glomerular filtration rate(GFR)increased in MACE group compared with non-MACE group(P<0.05).The level of ApoA-1 expression in cardiac death group,relapsed myocardial infarction group,stroke group and AP group was significantly lower than that in non-MACE group(P<0.05).The results of Logistic regression analyses showed that fasting blood glucose(FBG),triglyceride(TG),low-density lipoprotein-cholesterol(LDL-C)and ApoA-1 expression level were risk factors affecting cardiac death,relapsed myocardial infarction,stroke and AP in AMI patients after rhBNP treatment(P<0.05).The results of Pearson analysis showed that ApoA-1 expression was positively correlated to MACE(cardiac death,relapsed myocardial infarction,stroke and AP)in AMI patients after rhBNP treatment(P<0.05).Conclusion The level of ApoA-1 expression is a risk factor affecting MACE occurrence in AMI patients after rhBNP treatment.
Keywords：Acuter myocardial infarctionRecombinant human brain natriuretic peptideMajor adverse cardiovascular eventsApolipoprotein A-1
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 357-360,362 )