Relationship between level of serum lipoprotein associated phospholipase A2(Lp-PLA2)and coronary plaque vulnerability
Pu Chunfang
Liu Zheng
Abu Dunaibi
Wu Hongyan
Abstract：Objective To analyze the relationship between level of serum lipoprotein associated phospholipase A2(Lp-PLA2)and coronary plaque vulnerability.Methods The patients with coronary heart disease(CHD,n=100)were chosen from the First Affiliated Hospital of Xinjiang Medical University from Aug.2022 to Aug.2023.After examination of intravascular ultrasound(IVUS),the patients were divided into stable plaque group(SP group,n=57)and vulnerable plaque group(VP group,n=43).The both groups were given examination of optical coherence tomography(OCT)and detection of serum Lp-PLA2 level.The relationship among Lp-PLA2 level,OCT results,fiber cap thickness,thrombosis and plaque rupture,and diagnostic value of serum Lp-PLA2 to coronary plaque vulnerability were analyzed.Results Gender,age,smoking and drinking history were comparable between 2 groups(P>0.05).The indexes of diastolic blood pressure(DBP),systolic blood pressure(SBP),diabetes,hypertension and Gensini scores were higher in VP group than those in SP group(P<0.05).The level of fiber cap thickness was lower,and percentages of thrombosis and plaque rupture were higher in VP group than those in SP group(P<0.05).The level of serum Lp-PLA2 was higher in VP group than that in SP group(P<0.05).The level of serum Lp-PLA2 was negatively correlated to fiber cap thickness,and positively correlated to thrombosis and plaque rupture(P<0.05).Taken coronary vulnerable plaque formation as dependent variable(non-formation=0,formation=1),the results of multi-factor Logistics regression analysis showed that DBP,SBP,diabetes,hypertension,Gensini scores and Lp-PLA2 all were main factors affecting vulnerable plaques formation(P<0.05).The area under curve of serum Lp-PLA2 was 0.874,specificity was 81.40%,specificity was 82.46%and the optimal cutoff value was 217.96 ng/ml in diagnosing coronary plaque vulnerability.Conclusion The level of serum Lp-PLA2 is higher in CHD patients with coronary vulnerable plaques,and correlated to fiber cap thickness,thrombosis and plaque rupture.The increased level of serum Lp-PLA2 is a risk factor for coronary vulnerable plaques,which has higher diagnostic value to coronary plaque vulnerability.
Keywords：Coronary plaquesLipoprotein associated phospholipase A2Vulnerability
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 347-350 )