The relationship between peripheral blood GPR120 levels and eGFR and the value of predicting CI-AKI after coronary angiography

Wu Dengxuan; Wang Chaoju; Xu Dawen

doi:10.3969/j.issn.1674-4055.2024.03.20

Abstract：Objective To investigate the relationship between G-protein-coupled receptor 120(GPR120)levels and estimated glomerular filtration rate(eGFR)in patients undergoing coronary angiography,and to evaluate the value of GPR120 in predicting postoperative contrast acute kidney injury(CI-AKI).Methods A total of 293 patients who underwent coronary angiography at the Central Hospital of Panzhihua City from January 2020 to January 2023 were selected as the study subjects,among which 32 patients developed CI-AKI and were included in the observation group.Two hundred sixty-one cases without CI-AKI were included in the control group.The levels of GPR120 mRNA and eGFR in peripheral blood leukocytes of both groups were detected before surgery.The data of enrolled patients were collected by electronic medical record system,and 1:1 matching was performed between the two groups of patients according to the nearest matching method,and the score was calculated by Logistic regression model.The correlation between GPR120 mRNA and eGFR was analyzed.Logisitic regression model was used to analyze the independent relationship between GPR120 mRNA and CI-AKI after coronary angiography.Receiver operating curve(ROC)was plotted to evaluate the value of GPR120 mRNA in predicting CI-AKI after coronary angiography.Results After matching by propensity score,left ventricular ejection fraction,baseline eGFR,baseline eGFR<60 ml/(min·1.73 m2)ratio and GPR120 mRNA in observation group were lower than those in control group,contrast agent dosage was higher than that in control group,and contrast agent contact time was longer than that in control group(P<0.05).GPR120 mRNA was positively correlated with baseline eGFR(r=0.707,95%CI:0.559～0.812,P<0.001).With the increase of GPR120 mRNA level,the incidence of CI-AKI showed a decreasing trend after coronary angiography(P<0.05).After adjusting for confounding factors,the up-regulated expression of GPR120 mRNA still reduced the risk of CI-AKI after coronary angiography(P<0.05).The AUC value of GPR120 mRNA for CI-AKI after coronary angiography was 0.774,and the corresponding sensitivity and specificity were 65.62%and 84.37%,respectively.Conclusion GPR120 levels in patients undergoing coronary angiography are positively correlated with baseline eGFR and it can be used as a predictor of postoperative CI-AKI.