The predictive value of red cell distribution width and ft3 for the prognosis of female myocardial infarction with diabetes
Chang Xuewei
Zheng Weifeng
Qin Xinghan
Gu Yunfei
Wang Hao
Wei Yidong
Wei Jinghan
Abstract：Objective This study was designed to explore the value of red blood cell distribution width(RDW)and free triiodothyronine(fT3)on predicting long-term major adverse cardiac event(MACE)in female initial acute ST-segment elevation myocardial infarction(STEMI)patients with diabetes mellitus.Methods A total of 259 female patients with initial STEMI combined with diabetes who were hospitalized at the Luoyang Central Hospital affiliated with Zhengzhou University from June 2017 to December 2019 were selected for a follow-up of(31.81±9.02)months.Based on the occurrence of Major Adverse Cardiac Events(MACE),they were divided into the MACE group(59 cases)and the non-MACE group(200 cases).The COX regression method was used to analyze the influencing factors of MACE,and the Receiver Operating Characteristic(ROC)curve was constructed to evaluate the predictive value of RDW and fT3 for MACE.The Kaplan-Meier curve was used to analyze the cumulative survival rate without MACE.Results In the MACE group,the proportion of anterior wall myocardial infarction,the proportion of postoperative TIMI≤1,and higher RDW were higher than in the non-MACE group,while fT3 was lower than in the non-MACE group(P<0.05).Multifactorial Cox regression analysis showed that high RDW(HR=1.337,95%CI:1.092～1.636,P=0.005)and low fT3(HR=～0.615,95%CI:0.411～0.712,P<0.001)are independent risk factors for MACE in female STEMI patients with diabetes(P<0.05).The ROC curve results showed that the area under the ROC curve(AUC)for predicting MACE was 0.693 for RDW and 0.714 for fT3,with the combination of RDW and fT3 showing better predictive value(AUC=0.785,95%CI:0.725～0.844,sensitivity=79.7%,specificity=67.0%).The incidence of MACE in patients with high RDW and low fT3 was higher than in the other three groups,with the Log-Rank test(χ2=34.924,P<0.05).Conclusion High RDW and low fT3 have a certain predictive value for the long-term prognosis of female patients with initial STEMI combined with diabetes,with patients having high RDW and low fT3 experiencing a higher incidence of MACE.
Keywords：Myocardial InfarctionCoronary ArteryMajor Adverse Cardiac EventsTriiodothyronineRed Cell Distribution Width
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 324-327,334 )