Correlation between cardiac function and thyroid function in ICM patients with chronic decreased ejection fraction

Zhang Xiaohui; Yuan Hexin

doi:10.3969/j.issn.1674-4055.2024.03.06

Abstract：Objective To investigate the correlation between cardiac function and thyroid function in patients with ischemic cardiomyopathy(ICM)with chronic decreased ejection fraction.Methods 110 patients with ICM admitted to the hospital from May 2020 to May 2022 were selected as the study objects.The patients were divided into the control group(LVEF≥40%,n=49)and the study group(LVEF＜40%,n=61)according to whether the left ventricular ejection fraction(LVEF)was less than 40%.The NYHA classification,left ventricular end diastolic diameter(LVEDD),left atrial diameter(LAD),serum free thyroxine(FT4),free triiodothyronine(FT3)and thyroid stimulating hormone(TSH)levels were compared between the two groups.To compare the thyroid function indexes of ICM patients with chronic ejection fraction(CEF)reduction in different NYHA cardiac function grades.The correlation between cardiac and thyroid function was analyzed in ICM patients with regular decreased ejection fraction.Results There was no significant difference in NYHA cardiac function between the two groups(P＞0.05).LVEDD and LAD levels in the study group were higher than in the control group(P＜0.05).There was no significant difference in the level of FT4 between the two groups(P＞0.05).The level of FT3 in the study group was lower than that in the control group,and the level of TSH was higher than that in the control group(P＜0.05).There was no significant difference in the level of FT4 among ICM patients with chronic ejection fraction reduction in different NYHA cardiac function grades(P＞0.05).The FT3 levels in the Ⅲ and Ⅳ grade groups were lower than those in the I grade group,and the TSH levels were higher than those in the Ⅰ grade group.The FT3 level in the grade Ⅳ group is lower than that in the grade Ⅱ group,and the TSH level is higher than that in the grade Ⅱ group(P＜0.05).NYHA cardiac function grading was positively correlated with TSH(P＜0.05).LVEDD was negatively correlated with FT4 and FT3,and positively correlated with TSH(P＜0.05).LAD was negatively correlated with FT4 and FT3,and positively correlated with TSH(P＜0.05).Conclusion The level of serum FT3 in patients with chronic ejection fraction decrease ICM is low and negatively correlated with LVEDD and LAD.The serum TSH level was higher in patients with chronic ejection fraction reduction ICM,and was positively correlated with NYHA cardiac function grade,LVEDD and LAD.