Relationship among miR-126,in-stent restenosis,high sensitivity C-reactive protein and soluble vascular cell adhesion molecules-1 in patients with coronary heart disease after PCI
Dong Qianru
Zhao Zinan
Zhang Yatong
Wang Tingting
Fu Kun
Wang Rong
Lu Hui
Wang Jin
Abstract：Objective To analyze the relationship among peripheral blood miR-126,in-stent restenosis(ISR),high sensitivity C-reactive protein(hs-CRP)and soluble vascular cell adhesion molecules-1(sVCAM-1)in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods CHD patients(n=103,case group)undergone PCI were chosen from Beijing Aerospace General Hospital from Feb.2021 to Feb.2022.The case group was divided into acute myocardial infarction group(AMI group,n=32),unstable angina pectoris group(UAP group,n=42)and stable angina pectoris group(SAP group,n=29),and also divided into ISR group and non-ISR group according to ISR occurrence status after PCI.In addition,the cases without CHD with healthy examinations were chosen into control group(n=50).The levels of peripheral blood miR-126,hs-CRP and sVCAM-1 were detected,and ISR occurrence after PCI was observed.The correlation among miR-126 level,in-stent restenosis after PCI,and levels of hs-CRP and sVCAM-1 was analyzed.Results The level of miR-126 was significantly lower,and levels of hs-CRP and sVCAM-1 were significantly higher in case group than those in control group(P<0.05).The comparison in levels of miR-126,hs-CRP and sVCAM-1 showed statistical significance among AMI group,UAP group and SAP group(P<0.05).The level of miR-126 was significantly lower in AMI group than that in UAP group and SAP group(P<0.05),and significantly lower in UAP group than that in SAP group(P<0.05).The levels of hs-CRP and sVCAM-1 were significantly higher in AMI group than those in UAP group and SAP group(P<0.05),and significantly higher in UAP group than that in SAP group(P<0.05).The level of miR-126 was significantly lower,and levels of hs-CRP and sVCAM-1 were significantly higher in ISR group than those in non-ISR group(P<0.05).The level of miR-126 was negatively correlation to levels of hs-CRP and sVCAM-1 significantly in CHD patients(P<0.05).The level of hs-CRP was positively correlated to sVCAM-1 level significantly in CHD patients(P<0.05).Conclusion The level of miR-126 is closely correlated to ISR in CHD patients after PCI,and ISR may be improved through inflammatory responses and atherosclerosis.
Keywords：Coronary heart diseasePercutaneous coronary interventionIn-stent restenosisHigh sensitivity C-reactive proteinSoluble vascular cell adhesion molecules-1
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 262-265 )