Relationship between promoter methylation of ABCG1 and ANGPTL2 and heart failure in patients with coronary heart disease
Yan Chunhui
You Sanli
Xu Qin
Yuan Lili
Wang Chaohua
Abstract：Objective To analyze the relationship between promoter methylation of adenosine triphophate(ATP)-binding cassette(ABC)transporter G1(ABCG1)and angiopoietin-like protein 2(ANGPTL2)and heart failure in patients with coronary heart disease(CHD).Methods A total of 120 patients with CHD admitted to the hospital were enrolled between March 2020 and March 2022.According to the presence or absence of heart failure,they were divided into a combination group(n=26)and a CHD group(n=94).The levels of serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)were detected by full-automatic biochemical analyzer.The left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),and left ventricular end-systolic diameter(LVESD)were detected by echocardiography.The methylation of ABCG1 and ANGPTL2 genes was detected by specific PCR.The mRNA levels of ABCG1 and ANGPTL2 genes were detected by real-time fluorescence quantitative polymerase chain reaction.The influencing factors of heart failure were analyzed by Logistic regression analysis.Results There were significant differences in LDL-C,LVEF,LVEDD,LVESD,promoter methylation of ABCG1 and ANGPTL2 genes between the two groups(P<0.05).LVESD,LVEF,methylation of ABCG1 and ANGPTL2 were risk factors for heart failure.LVESD in patients with methylation of ABCG1 and ANGPLT2 was higher than that without methylation(P<0.05),while LVEF was lower than that without methylation(P<0.05).The mRNA levels of ABCG1 and ANGPTL2 genes in patients with methylation of ABCG1 and ANGPLT2 were significantly lower than those without methylation(P<0.05).Conclusion The methylation of ABCG1 and ANGPTL2 genes is a risk factor of heart failure in CHD patients.Detection of the methylation status can provide scientific support for the diagnosis and treatment of heart failure in coronary heart disease.
Keywords：Coronary Heart DiseaseAdenosine Triphosphate Binding Cassette Transporter G1Angiopoietin-Like Protein 2Heart Failure
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 180-184 )