Efficacy and safety of iodixanol administrated during emergency PCI in patients with ST-segment elevation myocardial infarction
Song Xuelian
Liu Litian
Yu Hangwei
Zhang Feifei
Wang Fan
Li yingxiao
Dang Yi
Abstract：Objective To discuss the efficacy and safety of iodixanol administrated during emergency percutaneous coronary intervention(PCI)in patients with ST-segment elevation myocardial infarction(STEMI).Methods STEMI patients(n=80)undergone emergency PCI were chosen from People's Hospital of Hebei Province from Jan.2020 to Dec.2020,and divided,according to contrast agent types,into test group(given iodixanol)and control group(given ioversol,each n=40).The baseline materials were collected from the patients,the quality of vascular imaging and adverse reactions were observed,and serum creatinine(SCr)and estimated glomerular filtration rate(eGFR)from 48 h to 72 h after the operation were recorded in 2 group.The patients were followed up 30 d after the operation,and incidence of targe lesion events were recorded including revascularization,stroke,in-stent thrombosis,cardiac death and myocardial infarction(MI).Results The clinical baseline materials had no significant difference between 2 groups(P>0.05),and results of vascular imaging were clear in 2 groups.The incidence rates of perioperative adverse reactions and levels of SCr and eGFR had no significant differences between 2 groups(P>0.05),but postoperative SCr increased[(91.52±33.83)μmol/L vs.(76.89±16.89)μmol/L,P<0.05]in control group,and had no significant changes in test group.Conclusion Iodixanol has less effect on kidney function and is safer in STEMI patients during emergency PCI.
Keywords：ST-segment elevation myocardial infarctionEmergency percutaneous coronary interventionIodixanol
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 177-179 )