Changes of autonomic nervous system activity after radiofrequency ablation for idiopathic premature ventricular contraction
Ding Bing
Dai Yunlang
He Linyan
Xie Liqian
Abstract：Objective Radiofrequency catheter ablation(RFCA)is a standard therapy for idiopathic premature ventricular contraction(IPVC).To determine the preoperative and postoperative activities of autonomic nervous system(ANS)in patients received RFCA in low,medium and high loading.Methods IPVC patients(n=200)undergone RFCA were retrospectively analyzed from June 2017 to Mar.2021.Among 200 patients,there were 179 patients(89.5%)with successful RFCA.The patients with successful RFCA were divided into low-loading group(loading≤15%),mid-loading group(loading from 15%to 25%)and high-loading group(loading≥25%).The clinical data,parameters of heart rate variability(HRV),heart rate turbulence(HRT)and deceleration capacity of rate(DC)were reviewed in all groups with different RFCA sites.Results The mean heart rate(HRmean),SDANN,SDNN,index of SDNN,rMSSD and pNN50 all were higher,and radio of LF to HF(LF/HF)was lower in high-loading group than those in low-loading group.After RFCA,SDNN,SDNN index,SDANN,rMSSD,pNN50,TS and DC decreased significantly(P<0.01),and LF/HF and TO increased significantly(P<0.01).The preoperative IPVC loading was positively correlated to LVEDd,HRmean,SDNN index,SDANN,rMSSD and pNN50,and negatively correlated to TC,LDL-C,LVEF and LF/HF.The results of regression analysis showed that IPVC loading was positively correlated to HRmean(P<0.01),SDANN(P<0.01)and rMSSD(P<0.01).Conclusion With the increase of IPVC loading,both sympathetic and vagal nerve activities,mainly sympathetic nerve activities,are enhanced.IPVC occurrence may be related to impaired ANS balance regulation.RFCA can reduce the activities of both sympathetic and vagal nerves.
Keywords：Idiopathic premature ventricular contractionRadiofrequency catheter ablationHeart rate variability
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 82-87 )