Causal relationship between atopic dermatitis and atrial fibrillation based on two-sample Mendelian randomization analysis
You Yaping
Fan Shaowei
Xue Wenjing
Hu Yuanhui
He Qingyong
Abstract：Objective To discuss the causal relationship between atopic dermatitis(AD)and atrial fibrillation(AF)by applying two-sample Mendelian randomization analysis.Methods The data from a gene-wide association study(GWAS)were analyzed with AD as exposure factor and AF as outcome variable.The two-sample Mendelian randomization analysis was conducted by using methods of inverse variance-weighted(IVW),MR-Egger,WM,Simple Mode and Weighted Mode,and heterogeneity tests,sensitivity analysis and pleiotropy analysis were carried out.Results There were totally 18 single nucleotide polymorphisms(SNP)included.The results of IVW analysis showed that AD was a risk factor of AF occurrence(OR=1.027,95%CI:1.00～1.05,P=0.043).The results of heterogeneity tests showed that there was no potential heterogeneity observed,and sensitivity was stable and reliable and there was no pleiotropy.Conclusion There is a causal relationship between AD and AF.It is necessary to find and intervene early potential AF in AD patients.
Keywords：Atrial fibrillationAtopic dermatitisMendelian randomization
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 77-81 )