Risk factors of dilated cardiomyopathy complicated by pulmonary arterial hypertension and their influence on prognosis
Tan Huihui
Wang Baohua
Jiang Hui
Abstract：Objective To discuss the risk factors of dilated cardiomyopathy(DCM)complicated by pulmonary arterial hypertension(PAH)and their influence on prognosis.Methods DCM patients(n=100)were chosen from Municipal Hospital of Qingdao City from Jan.2020 to Apr.2022,and all patients were divided,according whether they were complicated by PAH or not,into PAH group(n=34)and non-PAH group(n=66).The baseline materials were compared between 2 groups.The risk factors of DCM complicated by PAH were analyzed by using multi-factor Logistic regression analysis,and incidence rates of major adverse cardiovascular events(MACE)were recorded after 1-y followed-up.Results The number of patients with grades Ⅲ to Ⅳ of NYHA classification was significantly higher,and QRS wave of electrocardiogram,N-terminal pro-brain natriuretic peptide(NT-proBNP),albumin(ALB),left atrial diameter(LAD)and pulmonary artery systolic pressure(PASP)were significantly higher in PAH group than those in non-PAH group(P＜0.05).The results of multi-factor Logistic regression analysis showed that QRS wave of electrocardiogram,NT-proBNP,ALB and LAD were risk factors of PAF in DCM patients(P＜0.05).The patients were followed up to Apr.30,2023,there were 2 cases missed in PAH group and 3 missed in non-PAH group.The incidence rates of MACE were significantly higher in PAH group than those in non-PAH group(P＜0.05).Conclusion The risk factors of PAF in DCM patients include QRS wave of electrocardiogram,NT-proBNP,ALB and LAD,and DCM complicated by PAH can promote incidence rates of MACE,which should be paid more attention to in clinical practice.
Keywords：Dilated cardiomyopathyPulmonary arterial hypertensionRisk factorsPrognosisMajor adverse cardiovascular events
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1353-1355 )