Risk factors of asthenia and correlation between them and systemic inflammatory response indexes in elderly patients with coronary heart disease
Jiao Lili
Zhou Jinfeng
Abstract：Objective To discuss the risk factors for asthenia and correlation between them and systemic inflammatory response indexes(SIRI)in elderly patients with coronary heart disease(CHD).Methods Elderly CHD patients(n=175)were retrospectively analyzed,Fried scale was used for reviewing asthenia,and all patients were divided,according to reviewing results,into asthenia group and non-asthenia group.The influence factors related to asthenia were analysis,and risk factors for asthenia were analyzed by using multi-factor Logistic regression analysis.The predictive cutoff value of SIRI to asthenia was analyzed,and AUC and the optimal cutoff value were determined by using ROC curve.Results There were totally 175 elderly CHD patients chosen in this study,including 103(58.9%)in asthenia group and 72(41.1%)in non-asthenia group.The results of single-factor analysis showed that there were significant differences in stroke,chronic obstructive pulmonary disease(COPD),cardiac insufficiency,age,systolic blood pressure(SBP),monocytes and SIRI between 2 groups(P＜0.05).The results of binary Logistic regression analysis showed that COPD,age,SBP and SIRI were independent risk factors for asthenia in elderly CHD patients.AUC of SIRI in predicting asthenia was 0.623(SE=0.043,P＜0.05,95%CI:0.538～0.707)and the optimal cutoff value was 1000.Conclusion COPD,age,SBP and SIRI can increase the risk of asthenia,and SIRI has some predictive value to asthenia diagnosis in elderly CHD patients.
Keywords：Coronary heart diseaseAstheniaRisk factorsSystemic inflammatory response indexes
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1330-1333 )