Correlation among nuclear factor erythropoietin 2 related factor 2,heme oxygenase 1,miR-140,oxidative stress,heart function grading and ventricular remodeling in patients with chronic heart failure
Pu Yongmei
Men Rumei
Liu Cong
Meng Qinglan
Abstract：Objective To discuss the relationship among nuclear factor erythropoietin 2 related factor 2(Nrf2),heme oxygenase 1(HO-1),miR-140,oxidative stress,heart function grading and ventricular remodeling in patients with chronic heart failure(CHF).Methods CHF patients(n=168)were chosen into study group and healthy controls matched by age and sex(n=70)were chosen into control group from the Third Department of Cardiology in People's Hospital of Cangzhou City from Oct.2020 to Dec.2022.The expression of serum miR-140 was detected by using RT-qPCR.The expressions of serum Nrf2 and HO-1 and oxidative stress indexes were detected by using ELISA.The left ventricular mass index(LVMI)was examined and calculated by using echocardiography.Results The levels of Nrf2 and HO-1 increased,and expression of miR-140 decreased in study group compared with control group(P<0.05).The results of ROC curve analysis showed that AUC of miR-140 was 0.803(95%CI:0.734～0.895,P<0.001)and AUC of Nrf2 was 0.796(95%CI:0.705～0.873,P<0.001).HO-1(AUC=0.736,95%CI:0.655～0.810,P<0.001)could well distinguish control group from study group.The expression of miR-140 was negatively correlated to Nrf2(r=-0.824,P<0.001)and HO-1(r=-0.752,P<0.001)in CHF patients.The oxidative stress indexes,heart function indexes and LVMI were negatively correlated to miR-140 expression,and positively correlated to Nrf2 and HO-1(P<0.001).Along with heart grade increased,the levels of Nrf2 and HO-1 increased gradually,and miR-140 expression decreased gradually(P<0.05).Conclusion The expression of miR-140 decreases and levels of Nrf2 and HO-1 increase in CHF patients,which can reflect heart function and oxidative stress response,and are expected to become candidate biological molecules for CHF.
Keywords：Nuclear factor erythropoietin 2 related factor 2Heme oxygenase 1Chronic heart failureOxidative stressVentricular remodeling
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1325-1329 )