Relationship among blood uric acid level,carotid atherosclerotic plaque and 10-y cardiovascular disease risks in patients with type 2 diabetes mellitus
Yang Yuhuan
Wang Jun
Ma Mao
Abstract：Objective To discuss the relationship among level of blood uric acid(BUA)level,carotid atherosclerotic plaque(CAP)and risks of 10-y cardiovascular disease in patients with type 2 diabetes mellitus(T2DM).Methods T2DM patients(n=6667)were chosen from Department of Health Medicine in the First Affiliated Hospital of Xi'an Jiaotong University from Jan.2020 to Dec.2021.According to BUA level>420 umol/L in males and BUA>360 umol/L in females as hyperuricemia,the patients were divided into hyperuricemia group(n=1217)and non-hyperuricemia group(n=5450).The correlation among BUA level,CAP and risks of Chinese 10-y ischemic cardiovascular disease(ICVD)was analyzed by using single-factor and multi-factor Logistic regression analysis.Results The incidence of CAP was 39.3％in hyperuricemia group and 34.6％in non-hyperuricemia group(P<0.001).The risks of 10-y ICVD was 8.08％in hyperuricemia group and 7.02％in non-hyperuricemia group(P<0.001).Age and levels of body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),creatinine(Cr),total cholesterol(TC),low-density lipoprotein-cholesterol(LDL-C)and triglyceride(TG)increased,and level of high-density lipoprotein-cholesterol(HDL-C)decreased in hyperuricemia group compared with non-hyperuricemia group(P<0.05).The results of multi-factor Logistic regression analysis showed that BUA level was correlated to carotid atherosclerosis(OR=1.001,95％CI:1.000～1.002,P=0.010)and risks of cardiovascular diseases(OR=1.001,95％CI:1.001～1.003,P=0.03).Conclusion The level of BUA is correlated to CAP and risks of 10-y cardiovascular diseases,and hyperuricemia may contribute to cardiovascular disease development in T2DM patients.
Keywords：Carotid atherosclerotic plaqueBlood uric acidCardiovascular disease risk
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1322-1324,1333 )