Curative effect and safety of sakubatril-valsartan in elderly patients with non-heart failure with reduced ejection fraction
Wu Yuntao
Tian Guoxiang
Chen Yanmei
Liu Lixin
Bi Lei
Yao Lu
Zhu Runxiu
Abstract：Objective To observe the curative effect and safety of sakubatril-valsartan in elderly patients with non-heart failure with reduced ejection fraction(non-HFrEF).Methods The patients with non-HFrEF(n=100)were chosen from Department of Geriatric Medicine in the Seventh Medical Center of Chinese PLA General Hospital from Jan.2018 to Dec.2020,and they were divided,according to using or not using sakubatril-valsartan,into observation group(n=57)and control group(n=43).The changes of recovery rate of NYHA classification of heart function,6-minute walk distance(6MWD),N-terminal pro-brain natriuretic peptide(NT-proBNP)and left ventricular ejection fraction(LVEF),and incidence of adverse reactions were observed in 2 groups before treatment and after treatment for 6 months.Results In observation group,heart function,quality of life and recovery rate of NYHA classification of heart function were significantly improved after treatment for 6 months.Compared with before treatment,the total 6MWD was higher[(299.6±42.9)vs.(118.1±36.1),P<0.05],NT-ProBNP was lower[(2190.2±531.8)vs.(9718.1±380.1)pg/ml,P<0.05],and LVEF had no significant changes[(52.7±2.1)vs.(51.0±2.1),P<0.05]in observation group after treatment.The total 6MWD was higher[(299.6±42.9)vs.(129.1±40.1),P<0.05],NT-proBNP was lower[(2190.2±531.8)vs.(4191.2.1±491.2)pg/ml,P<0.05]in observation group than those in control group,and LVEF had no significant changes[(52.7±2.1)vs.(50.9±1.9),P>0.05]in observation group compared with control group.The adverse reactions were less during observation period.Conclusion Sacubitril-vaisartan can significantly promote the total 6MWD,reduce NT-ProBNP level and improve heart function with less adverse reactions.Sacubitril-vaisartan has higher curative effect and safety,which provides a new therapeutic method for elder patients with non-HFrEF.
Keywords：Sakubatril-valsartanNon-heart failure with reduced ejection fractionAgednessCurative effect
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1314-1317 )