Correlation between Helicobacter pylori infection and carotid atherosclerosis in people with physical examinations
Yang Yuhuan
Su Shi
Li Xin
Zhang Mingming
Wang Jun
Ma Mao
Abstract：Objective To discuss the relationship between carotid atherosclerosis(CAS)and infection of Helicobacter pylori(HP)in people with physical examinations.Methods The cases(n=36527)with HP detection and carotid artery ultrasound examination were chosen from Department of Health Medicine in the First Affiliated Hospital of Xi`an Jiaotong University from Jan.2015 to Oct.2022.All patients were divided into CAS group(n=16436)and non-CAS group(n=20091).The correlation between CAS and HP infection was analyzed by using single-factor and multi-factor Logistic regression analysis.There were 1021 cases followed up for 5 y to 7 y and CAS development was analyzed.Results The infection rate of HP was 32.4%in CAS group and 30.3%in non-CAS group(P<0.001).The male cases,age,percentages of hypertension,diabetes and dyslipidemia,body mass index(BMI),and levels of aspertate aminotransferase(AST),uric acid(UA),fasting blood glucose(FBG),total cholesterol(TC),low-density lipoprotein-cholesterol(LDL-C),triglyceride(TG)and albumin(ALB)were higher,and level of high-density lipoprotein-cholesterol(HDL-C)was lower in CAS group than those in non-CAS group(P<0.05).The results of multi-factor Logistic regression analysis showed that HP infection(OR=1.087,95%CI:1.030～1.147,P=0.003),age(OR=1.007,95%CI:1.003～1.110,P<0.001),male(OR=1.804,95%CI:1.650-1.972,P<0.001),BMI(OR=0.973,95%CI:0.963-0.982,P<0.001),hyperuricacidemia(OR=1.001,95%CI:1.001～1.002,P<0.001),hypertension(OR=1.193,95%CI:1.105～1.288,P<0.001)and diabetes(OR=1.510,95%CI:1.304～1.748,P<0.001)all were correlated to CAS.After 5y or 7y follow-up,ACS incidence rate was higher in cases with persistent HP positive than that in cases without HP infection(68.8%vs.59.7%,P=0.005).Conclusion HP infection is correlated to CAS and may improve the occurrence of cardiovascular diseases.
Keywords：Helicobacter pylori infectionCarotid atherosclerosis
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1208-1211 )