Influence of Gelanxinning Soft Capsule on NLRP3 inflammatory reaction in patients with coronary microvascular disease after PCI
Jiang Hongying
Cheng Gong
Wang Yiyang
Zhao Hui
Liang Chenyuan
Jiang Ruijia
Ren Yuanyuan
Chen Liang
Xu Bailing
Fang Wei
Abstract：Objective To discuss whether Gelanxinning Soft Capsule may protect against injury of coronary microvascular disease(CMVD)through inhibiting NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammatory response or not after percutaneous coronary intervention(PCI).Methods The patients(n=78)received successful PCI due to coronary heart disease(CHD)were chosen from Department of Cardiovascular Medicine in People's Hospital of Shaanxi Province from July 2021 to Sept.2022.After the operation the patients suffered from repeated attack of angina pectoris(AP)and normal results of coronary angiography(CAG).The coronary microvascular function was reviewed through detecting coronary flow reserve(CFR)by using single photo emission computerized tomography(SPECT).The patients with CFR<2.0(n=78)were selected into the study,and they were randomly divided into test group(n=38)and control group(n=40).The test group was treated with Gelanxinning Soft Capsule and routine Western drugs and control group was treated with only routine Western drugs.The changes of levels of NLRP3 and interleukin-8(IL-18)and scores of Seattle Angina Questionnaire(SAQ)were compared between 2 groups before treatment and 2 months after treatment.Results After treatment for 2 months,NLRP3 level decreased in 2 groups,and NLRP3 was significantly lower in test group than that in control group(P<0.01).After treatment,the level of IL-18 had no statistical difference between 2 groups(P>0.05),but its decrease was more significant in test group compared with control group.After treatment for 2 months,SAQ scores were higher thanbefore treatment in 2 groups,and was higher in test group than that in control group(P<0.05).Conclusion Both routine Western therapy and Gelanxinning Soft Capsule can reduce NLRP3 level and promote SAQ scores,while Western therapy combined with Gelanxinning Soft Capsule has higher improving effect on NLRP3 level and SAQ scores.Gelanxinning Soft Capsule possibly ameliorates CMVD through inhibiting NLRP3 inflammatory response.
Keywords：Coronary microvascular diseaseNOD-like receptor thermal protein domain associated protein 3Interleukin-18
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1189-1193 )