Correlation among left ventricular ejection fraction,N-terminal pro-brain natriuretic peptide and curative effect of Qiliqiangxin Capsules combined with Isosorbide Mononitrate Capsules on chronic heart failure
Cui Caixia
Zhang Lixia
Sun Jing
Huo Yan
Shi Huijuan
Sun Tingting
Wang Yujuan
Zhai Lina
Abstract：Objective To analyze the correlation among left ventricular ejection fraction(LVEF),N-terminal pro-brain natriuretic peptide(NT-proBNP)and curative effect of Qiliqiangxin Capsules combined with Isosorbide Mononitrate Capsules on chronic heart failure(CHF).Methods CHF patients(n=118)treated with Qiliqiangxin Capsules combined with Isosorbide Mononitrate Capsules were chosen from the Affiliated Hospital of Changzhi Institute of Traditional Chinese Medicine from Jan.2017 to Jan.2021.All patients were divided,according to curative effect,into effective group and ineffective group(each n=59).The general clinical materials were collected,and risk factors affecting curative effect were analyzed by using multi-factor Logistic regression analysis.A ROC curve was established for analyzing the diagnostic value of LVEF and NT-proBNP to curative effect.The correlation among LVEF,NT-proBNP and heart function was analyzed by using Pearson correlation analysis.Results The body mass index(BMI),systolic blood pressure(SBP),NT-proBNP and left ventricular end-diastolic diameter(LVEDd)were higher,and LVEF was lower in ineffective group than those in effective group(P<0.05).The results of multi-factor Logistic regression analysis showed that NT-proBNP,LVEF and LVEDd were independent factors affecting curative effect(P<0.05).The results of ROC curve analysis showed that AUC of LVEF was 0.746 and AUC of NT-proBNP was 0.797 in predicting curative effect on CHF,and AUC of LVEF combined with NT-proBNP was 0.901(P<0.05).The results of Spearman correlation analysis showed that NYHA classification was negatively correlated to LVEF(r=-0.634,P<0.001),and positively correlated to NT-proBNP(r=0.773,P<0.001).The results of Pearson correlation analysis showed that NT-proBNP was negatively correlated to LVEF(r=-0.507,P<0.001).Conclusion LVEF and NT-proBNP have some clinical value to assessing CHF status and curative effect of Qiliqiangxin Capsules combined with Isosorbide Mononitrate Capsules.
Keywords：Left ventricular ejection fractionN-terminal pro-brain natriuretic peptideChronic heart failureQiliqiangxin CapsulesIsosorbide Mononitrate Capsules
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1185-1188 )