Clinical characteristics and subtype analysis of adult left ventricular myocardial densification imperfect

Feng Yunfei; Ning Lili; Wang Huaigen; Zhang Hanzhao; Deng Zhengrong; Ni Yajuan; Ye Yulan; Ma Aiqun; Wang Tingzhong

doi:10.3969/j.issn.1674-4055.2023.09.20

Abstract：Objective We conducted a multicenter clinical observational study to comprehensively describe the clinical features of adult LVNC and the distribution of different subtypes and further analyze the correlation between the degree of noncompaction and cardiac structure and function.Methods This was a retrospective multicenter study.Patients with diagnosed or suspected LVNC between January 2010 and April 2022 from 4 hospitals in northwestern China were enrolled.Patients aged≥18 years and who fulfilled the Jenni criteria by echocardiography or the Petersen criteria by cardiovascular magnetic resonance were included.Patients with incomplete baseline data were excluded.We collected their baseline clinical data,including demographic characteristics,comorbidities,clinical manifestations,treatment,imaging,and electrocardiographic features.Results A total of 244 patients were finally included.The median age of patients at diagnosis was 48 years(35～59 years),and 70.6%were male.The median left ventricular ejection fraction(LVEF)was 46%(35%～64%).LVEF<50%was present in 131 patients(53.7%),and LV dilation was present in 154 patients(63.1%).Among the 163 patients who completed cardiac magnetic resonance,the median,minimum end-diastolic compaction thickness was 3.60 mm(2.95～5.00 mm),the median maximum end-diastolic non-compaction thickness was 12.50 mm(9.97～16.22 mm),and the median NC/C ratio was 2.80(2.40～3.60).One hundred twenty-six patients(51.6%)had at least one arrhythmia;premature ventricular contractions(35.2%)were the most common.The most common subtype of LVNC was dilated,with 118 patients(48.4%).Non-compaction parts were not significantly related to left ventricular end-diastolic diameter(LVEDD)(rs=-0.078,P=0.337)and LVEF(rs=0.177,P=0.028);NC/C ratio was not significantly related to LVEDD(rs=-0.04,P=0.645)and LVEF(rs=-0.051,P=0.557).Conclusions The median age at diagnosis of adult LVNC was 48 years,and most of them were male;LVEF decreased in more than half of the patients;dilated LVNC was the most common clinical subtype;and there was no significant correlation between the degree of non-compaction and cardiac structure and function.