Effect of SGLT2i combined with ARB on blood pressure in elderly patients with isolated systolic hypertension complicated with type 2 Diabetes Mellitus

Li Baojuan; Chang Xin; Wang Kun

doi:10.3969/j.issn.1674-4055.2023.09.16

Abstract：Objective To investigate the effect of sodium-dependent glucose transporter 2 inhibitor(SGLT2i)combined with angiotensin Ⅱ receptor blocker(ARB)on blood pressure in elderly patients with isolated systolic hypertension with type 2 diabetes mellitus.Methods A total of 150 elderly patients with isolated systolic hypertension with type 2 diabetes mellitus who attended the outpatient clinic of the Department of Cardiology of Chengde Central Hospital from September 2019 to September 2022 were collected.The experimental group was treated orally with irbesartan 150 mg/d and daglizin 10 mg/day,while the control group was treated orally with irbesartan 150 mg/d combined with hydrochlorothiazide 12.5 mg/d.The changes in systolic blood pressure,pulse pressure,mean arterial pressure,and uric acid levels before and after treatment were compared with baseline,and the improvement rate of obesity and the adverse reactions of hypokalemia and urinary tract infection during treatment were compared.Results After the two groups of treatment,systolic blood pressure,pulse pressure,and mean arterial pressure were all lower than before treatment,and after 12 weeks of treatment,the systolic blood pressure and pulse pressure levels in the experimental group were 147.51±6.22 mmHg and 80.63±6.06 mmHg lower than those in the control group 150.47±6.77 mmHg and 83.27±6.06 mmHg,respectively,and the differences were statistically significant(P=0.006,P=0.008).The improvement rate of obesity in the experimental group was better than that in the control group,and the difference was statistically significant(P=0.034).The probability of hypokalemia during treatment was lower than that of the control group,and the difference was statistically significant(P=0.042).Conclusion SGLT2i combined with ARB can effectively reduce systolic blood pressure and pulse pressure in elderly patients with isolated systolic hypertension complicated with type 2 diabetes mellitus,and it is safe and reliable in clinics.